An understanding of drug interactions has become essential to
the practice of medicine. Since publication of the first edition of
this Concise Guide in 2001, our increasing pharmacopoeia-coupled
with prolonged human life spans-has made polypharmacy
Like the first edition of this unique pocket reference, the
Second Edition is written expressly for clinicians. With four new
contributors, this bestseller includes expanded sections on both
phase I and phase II metabolism, updates of existing chapters and
tables, new graphics, and extensive Web site references. Brand-new
chapters discuss P-glycoproteins, "minor" cytochrome P450 enzymes,
pain management with narcotic and nonnarcotic analgesics,
prescribing guidelines, and medicolegal issues.
This exceptionally practical guide is divided into four
1. An easy-to-read, succinct review of pharmacology, written
with clinicians in mind, explaining the importance of understanding
our metabolic system and pharmacokinetics and P-glycoprotein drug
2. Thorough, carefully referenced reviews of the most clinically
relevant phase I and phase II metabolic enzymes highlighted with
newly expanded tables and study cases.
3. A section unique to this book on drug interactions by medical
specialty, with drug tables arranged by how they are used in
specialties such as gynecology, infectious diseases, internal
medicine, neurology, oncology, psychiatry, and pain medicine.
4. Chapters on practical matters: prescribing guidelines, how to
identify drug interaction patterns, strategies for reviewing the
current literature, and medicolegal concerns.
Enhanced by detailed descriptions and clinically based
explanations, and complemented by a unique pocket guide to the most
common and potent inhibitors and inducers of drug metabolism, this
updated concise "how-to" guide will prove indispensable for busy
students, teachers, and practitioners in all medically