Dimensions: 304 Pages, 5.91 × 9.45 × 0.39 in
Published: March 30, 2001
The following ISBNs are associated with this title:
ISBN - 10: 047149433x
ISBN - 13: 9780471494331
Table of Contents
Introduction (B. Hall).
Genetic Control of Skeletal Development (G. Karsentry).
Early Steps in Limb Patterning and Chondrogenesis (S. Pizette &
General Discussion I.
Developmental Mechanisms of Vertebrate Limb Evolution (M.
Regulation of Chondrocyte Growth and Differentiation by Fibroblast
Growth Factor Receptor (D. Ornitz).
Defects of Human Skeletogenesis--Models and Mechanisms (S.
Genetic Control of the Cell Proliferation--Differentiation Balance
in the Developing Skull Vault: Roles of Fibroblast Growth Factor
Receptor Signalling Pathways (G. Morriss-Kay, et al.).
Craniosynostosis and Related Limb Anomalies (A. Wilkie, et
The Parathyroid Hormone-Related Protein and Indian Hedgehog
Feedback Loop in the Growth Plate (H. Kronenberg & U.
Cartilage Matrix Resorption in Skeletogenesis (W. Wu, et
Retinoid signalling and skeletal development (T. Underhill, et
General Discussion II.
Defects in Extracellular Matrix Structural Proteins in the
Osteochondrodysplasias (D. Cohn).
Genetic Control of Bone and Joint Formation (D. Kingsley).
The Molecular Basis of Osteoclast Differentiation and Activation
(T. Suda, et al.).
Clinical Disorders of Bone Resorption (G. Russell, et al.).
Index of Contributors.
From the Publisher
Brings together a cross-fertilization of ideas between human molecular genetics, develeopmental biology, tissue biology and the biochemistry of cell signalling pathways, in order to create new insights into the mechanisms of normal and abnormal skeletogenesis.
From the Jacket
This book brings together a cross-fertilization of ideas between
human molecular genetics, developmental biology, tissue biology and
the biochemistry of cell signalling pathways, in order to create
new insights into the mechanisms of normal and abnormal
skeletogenesis. This broad perspective is essential in order to
understand the aetiology of genetic diseases affecting skeletal
development at all levels from genotype to phenotype, i.e. from
mutation to syndrome.
The book encompasses normal and abnormal skeletogenesis process by
process, beginning with the signalling pathways that control early
patterning events, then the molecular control of osteoblast,
chondrocyte and osteoclast differentiation, joint formation and
finally osteoclast activity. Each step takes into consideration the
results of mouse gene cloning and knockout studies, human molecular
genetics, and new mouse studies stimulated by the human
information. Such an integrated approach is essential if this new
understanding is to be applied for future therapeutic strategies.