5-HT2C Receptors in the Pathophysiology of CNS Disease by Giuseppe Di Giovanni5-HT2C Receptors in the Pathophysiology of CNS Disease by Giuseppe Di Giovanni

5-HT2C Receptors in the Pathophysiology of CNS Disease

EditorGiuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo

Paperback | January 28, 2013

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Part of Springer's "The Receptors," series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors' therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson's disease, Prader-Willi Syndrome, Alzheimer's disease and epilepsy.
Title:5-HT2C Receptors in the Pathophysiology of CNS DiseaseFormat:PaperbackDimensions:572 pagesPublished:January 28, 2013Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617797200

ISBN - 13:9781617797200

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Table of Contents

Chapter 1 The making of the 5-HT2C receptorJose M. Palacios, Angel Pazos and Daniel HoyerChapter 2 Serotonin 5-HT2C receptors: chemical neuronatomy in the mammalian brainGuadalupe MengodChapter 3 The medicinal chemistry of 5-HT2C receptor ligandsMarcello Leopoldo, Enza Lacivita, Paola De Giorgio, Francesco Berardi, Roberto PerroneChapter 4 Insights into 5-HT2C receptor function gained from transgenic mouse modelsStephen J. BonaseraChapter 5 Serotonin 5-HT2C receptor signal transductionMaria N. Garnovskaya and John R. RaymondChapter 6 Homology modeling of 5-HT2C receptorsNicolas Renault, Amaury Farce, Philippe ChavatteChapter 7 5-HT2C receptor dimerizationKatharine Herrick-Davis and Dinah T. FarringtonChapter 8 RNA editing of 5-HT2C receptor and neuropsychiatric diseasesKazuya Iwamoto, Miki Bundo and Tadafumi KatoChapter 9 Serotonergic control of adult neurogenesis: focus on 5-HT2C receptorsAnnie DaszutaChapter 10 The constitutive activity of 5-HT2C receptors as an additional modality of interaction of the serotonergic systemSylvia Navailles, Philippe De DeurwaerdèreChapter 11 The 5-HT2C receptor subtype controls central dopaminergic systems: evidence from electrophysiological and neurochemical studiesGiuseppe Di Giovanni, Ennio Esposito and Vincenzo Di MatteoChapter 12 The role of serotonin-2C receptors in the pathophysiology of depressionEliyahu Dremencov, Joost HA Folgering, Sandra Hogg, Laurence Tecott and Thomas I.F.H. Cremers Chapter 13 5-HT2C receptors and suicidal behaviourFabio Panariello, Naima Javaid and Vincenzo De LucaChapter 14 The 5-HT2C receptor as a target for schizophreniaHerbert Y Meltzer, Liwen Sun and Hitoshi HashimotoChapter 15 Serotonin and reward-related behaviour: focus on 5-HT2C receptorsPaul J. Fletcher and Guy A. HigginsChapter 16 Tat-3L4F: a novel peptide for treating drug addiction by disrupting interaction between PTEN and 5-HT2C receptorAmy Hu, Lintao Jia, Jean-Christian Maillet, Xia ZhangChapter 17 The role of serotonin in eating behaviour: focus on 5-HT2C receptorsJason C.G. HalfordChapter 18 Physiological and pathophysiological aspects of 5-HT2C receptors in basal gangliaPhilippe De Deurwaerdère, Laurence Mignon and Marie-Françoise ChesseletChapter 19 Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatmentRichard M. KostrzewaChapter 20 The role of 5-HT2A/2C receptors in sleep and wakingJaime M. Monti and Héctor JantosChapter 21 Role of alternative splicing of the 5-HT2C in the Prader-Willi syndromeShivendra Kishore and Stefan StammChapter 22 The role of 5-HT2C receptor in epilepsyRita Jakus and Gyorgy BagdyChapter 23 The role of serotonin on attentional processes and executive functioning: focus on 5-HT2C receptorsEleftheria Tsaltas and Vasileios BoulougourisChapter 24 5-HT2C receptors in learningLópez-Vázquez Miguel Ángel, Gutiérrez-Guzmán Blanca Érika, Cervantes Miguel and Olvera-Cortés María EstherChapter 25 The role of 5-HT2C polymorphisms in behavioural and psychological symptoms of alzheimer's diseaseAntonia PritchardChapter 26 Ocular hypotension: involvement of serotonergic 5-HT2C receptorsNajam A. Sharif

Editorial Reviews

From the reviews:"The book is well presented with good use of diagrams . . There is a good mix of international authors with acknowledged leaders in the field being responsible for some key chapters. . In summary this is a useful book describing the properties of a receptor that may well turn out to be a therapeutically important drug target with selective ligands already being evaluated in phase II trials for control of appetite." (R. G. Hill, British Journal of Clinical Pharmacology, May, 2011)