A Biologic Approach to Environmental Assessment and Epidemiology

Hardcover | July 4, 2010

byThomas J. Smith, David Kriebel

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Environmental chemical hazards are a highly contentious topic in modern life. Nearly every nation on earth has faced its own environmental crises, and also shares perspectives on the possibility of global catastrophes. Of the many global concerns we face, the environmental issue is unique inmany ways. The greatest of these is the fundamental scientific nature of the issue, and the extent to which our opinions are formed based on high-level scientific inquiry and assessment. The two key fields of study on this issue, environmental epidemiology and exposure assessment, are still given separate names because of their separate historical roots and scientific traditions, but are seen increasingly as inseparable aspects of the same basic investigation. In this book, ThomasJ. Smith and David Kriebel assert that important advances in the quantification of environmental risks can only come through a true synthesis of the two fields. They have built a common biologic model of exposure, physiologic response, and disease, a synthesis of the various existing models whichserves to both simplify and improve the application of environmental epidemiology and exposure assessment to current and future environmental chemical risks.When exposure assessor and epidemiologist agree from the start on the model for their study, the conceptual framework for the study they design and the analyses they carry out are much more likely to yield useful exposure-risk information. An explicit biologic model of the apparent processes linkingexposure to disease should form the basis for any study seeking to quantify risk from environmental chemicals.

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Environmental chemical hazards are a highly contentious topic in modern life. Nearly every nation on earth has faced its own environmental crises, and also shares perspectives on the possibility of global catastrophes. Of the many global concerns we face, the environmental issue is unique inmany ways. The greatest of these is the funda...

Thomas J. Smith is a Professor of Industrial Hygiene at Harvard School of Public Health. David Kriebel is a Professor of Work Environment at the University of Lowell.

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Format:HardcoverDimensions:448 pages, 9.25 × 6.13 × 0.98 inPublished:July 4, 2010Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195141563

ISBN - 13:9780195141566

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Table of Contents

1. Introduction - Relating Disease to ExposureSection A. Exposure and Disease in Individuals2. Characteristics of Exposure3. Exposure Characterization for Epidemiology4. Personal Exposure-Tissue Concentration Relationships5. Biomarkers as Indicators of Exposure6. Disease Process ModelsSection B. Exposure and Disease in Populations7. Epidemiologic Evaluation of Environmental Hazards8. Uncertainty in Measuring Risk9. Dosimetry in EpidemiologySection C. Practical Applications of Disease Process Models10. Modeling Proportional Disease Processes11. Effects of Ammonia and Ozone on Respiratory Symptoms: Examples of Reversible Proportional Disease Processes12. Neurobehavioral Effects of Mercury and Popcorn Workers' Lung: Examples of Irreversible Proportional Diseases Processes13. Modeling Discrete Disease Processes14. Asthma and Indoor Air, Dermatitis and Metalworking Fluids: Examples of Discrete Reversible Disease Processes15. Irreversible Discrete Processes16. Where Do We Go From Here?