A Practical Guide To Rational Drug Design by Sun HongmaoA Practical Guide To Rational Drug Design by Sun Hongmao

A Practical Guide To Rational Drug Design

bySun HongmaoEditorSun Hongmao

Hardcover | October 12, 2015

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This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches.A Practical Guide to Rational Drug Designfocuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.

  • Discusses various tactics applicable to daily drug design
  • Readers can download the materials used in the book, including structures, scripts, raw data, protocols, and codes, making this book suitable resource for short courses or workshops
  • Offers a unique viewpoint on drug discovery research due to the author's cross-discipline education background
  • Explores the author's rich experiences in both pharmaceutical and academic settings
Dr. Sun received his BSc degree in chemistry and PhD degree in physics from University of Science and Technology of China (USTC). He was awarded his second PhD degree in medicinal and computational chemistry by Clark University and UMass Med School in 1997. Dr. Sun joined the faculty of Washington University Medical School at St. Louis...
Title:A Practical Guide To Rational Drug DesignFormat:HardcoverDimensions:292 pages, 9.41 × 7.24 × 0.98 inPublished:October 12, 2015Publisher:Woodhead PublishingLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0081000987

ISBN - 13:9780081000984

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Table of Contents

PART I Rational Drug Design 1. Structure of the target is available 2. Structure of the target is unavailable 3. Virtual screening (VS)PART II Chemoinformatics 1. QSAR modeling 2. Processing HTS results 3. Delivering modeling results