ABC Proteins: From Bacteria to Man

Other | January 7, 2003

byI Barry Holland, I Barry Holland, Susan P. C. Cole...

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ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated.

  • Phylogeny and Evoloution of ABC Transporters
  • Fundamental Aspects of the Mechanism of Action of ABC Transporters
  • Prokaryote ABC Transporters
  • Non-Mammalian Transporters
  • Multidrug Transporters
  • ABC Transporters, Physiological Roles and Human Disease
  • Full color throughout

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From the Publisher

ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findin...

Format:OtherDimensions:530 pages, 1 × 1 × 1 inPublished:January 7, 2003Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080481876

ISBN - 13:9780080481876

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Extra Content

Table of Contents

Preface.
Introduction.

PART 1-PHYLOGENY AND EVOLUTION OF ABC-TRANSPORTERS
Phylogenetic and Functional Classification of ABC (ATP-binding cassette) Systems
Membrane Topology of the Human ABC Transporter Proteins
Human and Drosophila ABC-Proteins

PART 2-FUNDAMENTAL ASPECTS OF THE MECHANISM OF ACTION OF ABC-TRANSPORTERS
Structure and Modular Organization of ABC-Transporters
Substrate Binding Sites in ABC-Transporters
Probing of Conformational Changes,Catalytic Cycle and ABC-Transporters Function
X-ray Structure of an Intact ABC-Transporter, MsbA

PART 3-PROKARYOTE ABC-TRANSPORTERS
Introduction to Bacterial ABC-Transport Systems
Import of Solutes by ABC-Transporters-The Maltose System
Crystal Structures of Periplasmic Solute Binding Proteins in ABC-Transport Complexes Illuminate their Function
Bacterial ABC-Transporters Involved in Protein Translocation
Bacterial Multidrug Resistance Mediated by ABC-Transporters
Structure and Function of Osmoregulated ABC Transporters

PART 4 -NON-MAMMALIAN EUKARYOTE ABC-TRANSPORTERS
Inventory & Evolution of Fungal ABC Protein Genes.
Fungal ABC Proteins in Clinical Drug Resistance & Cellular Detoxification
Drug Resistance Mediated by ABC Transporters in Parasites of Humans
The Plant ABC Transporter Superfamily: the Functions of a Few and Identities of Many

PART 5-MAMMALIAN MULTIDRUG RESISTANCE ABC-TRANSPORTERS
Solving the Problem of Multidrug Resistance: ABC Transporters in Clinical Oncology
Multidrug Resistance Protein 1 (ABCC1)
MRP2, the Apical Export Pump for Anionic Conjugates
The Multidrug Resistance Proteins 3-7
Lipid Transport by ABC Transporters
Role of ABCA1 in Cell Turnover and Lipid Homeostasis
Peroxisome ABC-Transporters
ABC-Transporters in Mitochondria
The Transporter Associated with Antigen Processing (TAP): A Peptide Transport and Loading Complex Essential for Cellular Immune Responses
The Sulphonylurea Receptor: an ABCC Transporter that Acts as an Ion Channel Regulator
ABC-Transporters and Human Eye Disease
Structure Function Analysis of CFTR