Abnormal Hemoglobins in Human Populations

Paperback | September 9, 2009

byFrank B. LivingstoneIntroduction byJonathan Marks

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Research on abnormal human hemoglobins (protein in blood that carries oxygen), has taught us about the inheritance, biochemistry, and distribution of these traits. Th is knowledge, coupled with mathematical research using computer models of population genetics, has enabled researchers to marry biological fact and genetic theory.

This volume places medical understanding in an evolutionary framework. Using published data on the frequencies of abnormal hemoglobins in the world's populations, Livingston analyzes and interprets these frequencies in the light of world distribution of diff erent forms of diseases such as malaria. He further develops the genetic theory of the evolutionary homeostasis.

Livingston discusses the relation of abnormal hemoglobins to endemic malaria and, shows how natural selection pressures explain the known distribution of these traits. Where non-coinciding distributions arise, the book presents other genetic, anthropological, evolutionary, and epidemiological evidence to explain these discrepancies. This classic work remains a useful sourcebook for professors and graduate students of anthropology, genetics, epidemiology, and hematology.

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Research on abnormal human hemoglobins (protein in blood that carries oxygen), has taught us about the inheritance, biochemistry, and distribution of these traits. Th is knowledge, coupled with mathematical research using computer models of population genetics, has enabled researchers to marry biological fact and genetic theory.This vo...

Jonathan Marks is a professor of anthropology, at the University of North Carolina, Charlotte. He earned his M.S. in genetics, and M.A. and Ph.D. in anthropology at the University of Arizona, and has conducted postdoctoral research in genetics at the University of California at Davis. Mark's work on "molecular anthropology" has been ...
Format:PaperbackDimensions:483 pages, 9 × 6.04 × 1.02 inPublished:September 9, 2009Publisher:Aldine TransactionLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0202362647

ISBN - 13:9780202362649

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Table of Contents

INTRODUCTION TO THE ALDINE TRANSACTION EDITION
PREFACE
LIST OF ILLUSTRATIONS
LIST OF TABLES

I INTRODUCTION
II THE ABNORMAL HEMOGLOBINS AND THALASSEMIA
III THE GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY
IV THE POPULATION GENETICS OF THE RED CELL DEFECTS
V SELECTION FOR THE RED CELL DEFECTS
VI EASTERN ASIA AND THE PACIFIC
VII INDIA, TIBET, PAKISTAN, AND CEYLON
VIII THE MIDDLE EAST AND EUROPE
IX NORTH AND WEST AFRICA
X CENTRAL AND EAST AFRICA
XI THE AMERICAS
XII CONCLUSIONS

BIBLIOGRAPHY
APPENDIX: THE FREQUENCIES OF THE RED CELL DEFECTS IN HUMAN POPULATIONS
INDEX TO APPENDIX