Abnormal Hemoglobins in Human Populations by Frank. B. Livingstone

Abnormal Hemoglobins in Human Populations

byFrank. B. Livingstone, Jonathan Marks

Paperback | September 15, 2009

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Research on abnormal human hemoglobins (protein in blood that carries oxygen), has taught us about the inheritance, biochemistry, and distribution of these traits. Th is knowledge, coupled with mathematical research using computer models of population genetics, has enabled researchers to marry biological fact and genetic theory.

This volume places medical understanding in an evolutionary framework. Using published data on the frequencies of abnormal hemoglobins in the world's populations, Livingston analyzes and interprets these frequencies in the light of world distribution of diff erent forms of diseases such as malaria. He further develops the genetic theory of the evolutionary homeostasis.

Livingston discusses the relation of abnormal hemoglobins to endemic malaria and, shows how natural selection pressures explain the known distribution of these traits. Where non-coinciding distributions arise, the book presents other genetic, anthropological, evolutionary, and epidemiological evidence to explain these discrepancies. This classic work remains a useful sourcebook for professors and graduate students of anthropology, genetics, epidemiology, and hematology.

About The Author

Frank B. Livingstone was professor emeritus of biological anthropology at the University of Michigan. He recieved the Martin Luther King Award from the Southern Christian Leadership Conference for his groundbreaking research on sickle cell anemia and is the author of Data on the Abnormal Hemoglobin's and Glucose-Six-Phosphate Deficien...

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Title:Abnormal Hemoglobins in Human PopulationsFormat:PaperbackDimensions:490 pages, 9 × 6.04 × 1.02 inPublished:September 15, 2009Publisher:Taylor and FrancisLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0202362647

ISBN - 13:9780202362649

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Table of Contents

INTRODUCTION TO THE ALDINE TRANSACTION EDITION
PREFACE
LIST OF ILLUSTRATIONS
LIST OF TABLES

I INTRODUCTION
II THE ABNORMAL HEMOGLOBINS AND THALASSEMIA
III THE GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY
IV THE POPULATION GENETICS OF THE RED CELL DEFECTS
V SELECTION FOR THE RED CELL DEFECTS
VI EASTERN ASIA AND THE PACIFIC
VII INDIA, TIBET, PAKISTAN, AND CEYLON
VIII THE MIDDLE EAST AND EUROPE
IX NORTH AND WEST AFRICA
X CENTRAL AND EAST AFRICA
XI THE AMERICAS
XII CONCLUSIONS

BIBLIOGRAPHY
APPENDIX: THE FREQUENCIES OF THE RED CELL DEFECTS IN HUMAN POPULATIONS
INDEX TO APPENDIX