Acids and Bases: Solvent Effects on Acid-Base Strength by Brian G. Cox

Acids and Bases: Solvent Effects on Acid-Base Strength

byBrian G. Cox

Paperback | February 28, 2013

not yet rated|write a review

Pricing and Purchase Info

$52.50

Earn 263 plum® points

Ships within 1-3 weeks

Ships free on orders over $25

Not available in stores

about

Acids and bases are ubiquitous in chemistry. Our understanding of them, however, is dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound changes in acid-base strengths and to the rates and equilibria of many processes: for example, synthetic reactionsinvolving acids, bases and nucleophiles; isolation of pharmaceutical actives through salt formation; formation of zwitter- ions in amino acids; and chromatographic separation of substrates. This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour innon-aqueous solvents. The behaviour is related where possible to that in water, but correlations and contrasts between solvents are also presented.Fundamental background material is provided in the initial chapters: quantitative aspects of acid-base equilibria, including definitions and relationships between solution pH and species distribution; the influence of molecular structure on acid strengths; and acidity in aqueous solution. Solventproperties are reviewed, along with the magnitude of the interaction energies of solvent molecules with (especially) ions; the ability of solvents to participate in hydrogen bonding and to accept or donate electron pairs is seen to be crucial. Experimental methods for determining dissociationconstants are described in detail.In the remaining chapters, dissociation constants of a wide range of acids in three distinct classes of solvents are discussed: protic solvents, such as alcohols, which are strong hydrogen-bond donors; basic, polar aprotic solvents, such as dimethylformamide; and low-basicity and low polaritysolvents, such as acetonitrile and tetrahydrofuran. Dissociation constants of individual acids vary over more than 20 orders of magnitude among the solvents, and there is a strong differentiation between the response of neutral and charged acids to solvent change. Ion-pairing and hydrogen-bondingequilibria, such as between phenol and phenoxide ions, play an increasingly important role as the solvent polarity decreases, and their influence on acid-base equilibria and salt formation is described.

About The Author

Dr Brian G. Cox was educated at the University of Melbourne, followed by academic research or teaching posts at the Australian National University, the University of Stirling, Cornell University, and the Max-Planck Institut fur biophys. Chemie, Gottingen. He subsequently held industrial positions of Corporate Research Associate with IC...
Universal: A Guide To The Cosmos
Universal: A Guide To The Cosmos

by Brian Cox

$35.45$45.50

In stock online

Available in stores

Forces Of Nature
Forces Of Nature

by Professor Brian Cox

$16.49$17.99

In stock online

Available in stores

Human Universe
Human Universe

by Professor Brian Cox

$16.02$17.99

In stock online

Available in stores

Shop this author

Details & Specs

Title:Acids and Bases: Solvent Effects on Acid-Base StrengthFormat:PaperbackDimensions:192 pages, 9.69 × 7.44 × 0.03 inPublished:February 28, 2013Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199670528

ISBN - 13:9780199670529

Look for similar items by category:

Customer Reviews of Acids and Bases: Solvent Effects on Acid-Base Strength

Reviews

Extra Content

Table of Contents

1. Introduction2. Acid-base equilibria: quantitative treatment3. Solvation and acid-base strength4. Solvation and acid-base strength5. Protic solvents6. High-basicity, aprotic solvents7. Low-basicity and low-polarity aprotic solvents8. Acid-base equilibria and salt formation9. Appendices: Dissociation constants in methanol and aprotic solventsIndex