Actin-Binding Proteins and Disease

Hardcover | November 26, 2007

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There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders. The volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole.

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From the Publisher

There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders. The volume is relevant to a wide readership including cell biologists interested in understanding how structura...

From the Jacket

This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymo...

Format:HardcoverDimensions:362 pages, 9.25 × 6.1 × 0.9 inPublished:November 26, 2007Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387717471

ISBN - 13:9780387717470

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Table of Contents

Overview of actin.- Actin Genetic Diseases.- Actin-binding drugs.- Filamentous actin as an autoantigen.- Actin Binding Protein Function and its Relation to Disease Pathology.- ADF/cofilin, actin dynamics and disease.- Gelsolin and disease.- Profilin and disease.- The roles of thymosin beta4 in cell migration and cell-to-cell signalling in disease.- Actin and actin binding proteins in cancer progression and metastasis.- Defects in actin and actin-binding proteins in leukocytes.- The role of PIP2 in actin, actin-binding proteins and disease.- Intracellular pathogens and the actin cytoskeleton.- Actin and its binding proteins in heart failure.