This book brings together a set of papers, many which grow out of presentations at a conference in Oxford in 2009 on addiction and self-control, by a set of thinkers who are united in believing that understanding agency and failures of agency requires engagement with the best science. Thepapers it collects attempts to illuminate the mechanisms involved in addiction and thereby to understand to what degree and in what ways actions driven by addiction are controlled by the agent, express his or her will or values, and the extent to which addicts are responsible for what they do. Some of the papers focus on the neuropsychological mechanisms involved, especially on the role of the midbrain dopamine system. Others focus on features of the behavior and the extent to which we can infer psychological mechanisms from behavior. The authors debate the best interpretation of thescientific evidence and how the scientific evidence bears upon, or can only be understand in the light of, philosophical theorizing about agency, control and responsibility.