Adenoviral Vectors for Gene Therapy

Other | May 1, 2002

byCuriel, David T., David T. Curiel

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Adenoviral Vectors for Gene Therapyprovides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors.

Key Features
* Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors
* Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement
* Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
* Discusses utility of adenoviral vectors in animal disease models
* Considers Federal Drug Administration regulations for human clinical trials

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From the Publisher

Adenoviral Vectors for Gene Therapyprovides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical a...

Format:OtherDimensions:890 pages, 1 × 1 × 1 inPublished:May 1, 2002Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080525962

ISBN - 13:9780080525969

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Table of Contents

Adenovirus Structure

Biology of Adenovirus Cell Entry

Adenovirus Replication

Adenoviral Vector Construction I: Mammalian Systems

Adenoviral Vector Construction II: Bacterial Systems

Propagation of Adenoviral Vectors: Use of PER.C6 Cells

Purification of Adenovirus

Targeted Adenoviral Vectors I: Transductional Targeting

Targeted Adenoviral Vectors II: Transcriptional Targeting

Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer

Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer

Innate Immune Responses to in Vivo Adenovirus Infection

Humoral Immune Response

Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy

High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications

Xenogenic Adenoviral Vectors

Hybrid Adenoviral Vectors

Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer

Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease

Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases

Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations

Imaging Adenovirus-Medicated Gene Transfer