Adenoviral Vectors For Gene Therapy

Hardcover | April 6, 2016

byDavid T. CurielEditorDavid T. Curiel

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Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

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From the Publisher

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing f...

From the Jacket

Adenoviral Vectors for Gene Therapy, Second Editionprovides detailed, comprehensive coverage of the gene delivery vehicles, based on the adenovirus, emerging as important tools in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research....

David T. Curiel, M.D., Ph.D. is the Director of the Cancer Biology Division of the Department of Radiation Oncology at Washington University School of Medicine. Dr. Curiel graduated medical school at Emory University in 1982, where he also completed his internship and residency in Internal Medicine. Dr. Curiel's scientific training inc...
Format:HardcoverDimensions:868 pages, 9.41 × 7.24 × 0.98 inPublished:April 6, 2016Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:012800276X

ISBN - 13:9780128002766

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Table of Contents

Adenovirus Structure Biology of Adenovirus Cell Entry Adenovirus Replication Adenoviral Vector Construction I: Mammalian Systems, Adenoviral Vector Construction II: Bacterial Systems Propagation of Adenoviral Vectors: Use of PER.C6 Cells Purification of Adenovirus Targeted Adenoviral Vectors I: Transductional Targeting Targeted Adenoviral Vectors II: Transcriptional Targeting Development of Attenuated Replication Competent Adenoviruses (ARCAs) for the treatment of Prostate Cancer Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer Innate Immune Responses to in Vivo Adenovirus Infection Humoral Immune Response Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications Xenogenic Adenoviral Vectors Hybrid Adenoviral Vectors Utiliity of Adenoviral Vectors in Animal Models of Human Disease I: Cancer Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations Imaging Adenovirus-Medicated Gene Transfer