Adoptive Immunotherapy: Methods and Protocols by Burkhard LudewigAdoptive Immunotherapy: Methods and Protocols by Burkhard Ludewig

Adoptive Immunotherapy: Methods and Protocols

EditorBurkhard Ludewig, Matthias W. Hoffmann

Paperback | November 9, 2010

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An authoritative collection of optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients. Taking advantage of the latest technologies, the authors present readily reproducible experimental protocols for the study of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and clinical applications and on the progress of selected approaches in clinical trials. Additional chapters cover the molecular definition of target antigens, mathematical modeling approaches to immunotherapy, and the utilization of regulatory T cells. The protocols make it possible to study the adoptive transfer of tailored antigen-specific immune cells and to improve the clinical application of adoptive immunotherapy.
Title:Adoptive Immunotherapy: Methods and ProtocolsFormat:PaperbackDimensions:516 pages, 9.02 × 5.98 × 0.07 inPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617375462

ISBN - 13:9781617375460

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Table of Contents

Exploiting Dendritic Cells for Active Immunotherapy of Cancer and Chronic InfectionDavid O'Neill and Nina BhardwajA Mathematical Approach for Optimizing Dendritic Cell-Based ImmunotherapyGennady Bocharov, Neville J. Ford, and Burkhard LudewigDelivery of Tumor Antigens to Dendritic Cells Using Biodegradable MicrospheresYing Waeckerle-Men, Bruno Gander, and Marcus GroettrupRNA Transfection of Dendritic CellsFrank Grünebach, Martin R. Müller, and Peter BrossartIsolation and Generation of Clinical-Grade Dendritic Cells Using the CliniMACS SystemJohn D. M. Campbell, Christoph Piechaczek, Gregor Winkels, Edith Schwamborn, Daniela Micheli, Sonja Hennemann, and Jürgen SchmitzGeneration of Clinical Grade Monocyte-Derived Dendritic Cells Using the CliniMACS SystemThomas Putz, Hubert Gander, Reinhold Ramoner, Claudia Zelle-Rieser, Andrea Rahm, Walter Nussbaumer, Georg Bartsch, Lorenz Höltl, and Martin ThurnherAdenoviral Transduction of Dendritic CellsRienk Offringa, Kitty Kwappenberg, Martijn Rabelink, Delphine Rea, and Rob HoebenGeneration of Autologous Peptide- and Protein-Pulsed Dendritic Cells for Patient-Specific ImmunotherapyDavid O'Neill and Nina BhardwajPhenotypical and Functional Characterization of Clinical-Grade Dendritic CellsI. Jolanda M. de Vries, Gosse J. Adema, Cornelis J. A. Punt, and Carl G. FigdorDendritic Cells in Clinical Trials for Multiple MyelomaVolker L. Reichardt and Peter BrossartIdentification of Tumor-Associated Autoantigens With SEREXÖzlem Türeci, Dirk Usener, Sandra Schneider, and Ugur SahinApplication of Proteomics and Protein Analysis for Biomarker and Target Finding for ImmunotherapyPetra Weingarten, Petra Lutter, Andreas Wattenberg, Martin Blueggel, Sonja Bailey, Joachim Klose, Helmut E. Meyer, and Christoph HuelsIsolation and Expansion of Tumor-Reactive Cytotoxic T-Cell Clones for Adoptive ImmunotherapyHelga Bernhard, Burkhard Schmidt, Dirk H. Busch, and Christian PeschelTracking Adoptively Transferred Antigen-Specific T-Cells With Peptide/MHC MultimersNorbert Meidenbauer and Andreas MackensenGene Transfer of MHC-Restricted ReceptorsHelmut W. H. G. Kessels, Monika C. Wolkers, and Ton N. M. SchumacherImmunotherapy With CTL Restricted by Nonself MHCLiquan Gao, Anne-Marie Downs, and Hans J. StaussDesigning TCR for Cancer ImmunotherapyRalf-Holger Voss, Jürgen Kuball, Matthias TheobaldIsolation and Expansion of Tumor-Specific CD4+ T-Cells by Means of Cytokine SecretionChristian BeckerMethods for the Ex Vivo Characterization of Human CD8+ T Subsets Based on Gene Expression and Replicative History AnalysisNathalie Rufer, Patrick Reichenbach, and Pedro RomeroRegulatory T Cells in Antitumor Therapy: Isolation and Functional Testing of CD4+CD25+ Regulatory T-CellsHelmut Jonuleit and Edgar SchmittMonoclonal Antibody-Based Strategies in Autoimmunity and TransplantationLucienne ChatenoudProducing Bispecific and Bifunctional AntibodiesDipankar Das and Mavanur R. SureshAntibody-Cytokine Fusion Proteins for the Therapy of CancerGustavo Helguera and Manuel L. PenichetSynthesis and Biological Evaluation of a Paclitaxel ImmunoconjugateAhmad Safavy and Kevin P. RaischCytotoxic Tumor Targeting With scFv Antibody-Modified LiposomesCornelia Marty and Reto A. SchwendenerIntravenous Immunoglobin Treatment for Fibrosis, Atherosclerosis, and Malignant ConditionsIlan Krause and Yehuda ShoenfeldStudy of T-Cell Costimulatory Blockade In Vivo at a Single Cell LevelMinh Diem Vu and Xian Chang LiStem Cell Transplantation: Graft-Mediated Antileukemia EffectsWilliam J. Hogan and Hans Joachim DeegInfluence of Radiation Protocols on Graft-vs-Host Disease Incidence After Bone-Marrow Transplantation in Experimental ModelsSebastian Schwarte and Matthias W. HoffmannInduction of Chimerism and Tolerance Using Freshly Purified or Cultured Hematopoietic Stem Cells in Nonmyeloablated MiceNikos Emmanouilidis and Christian P. LarsenInduction of Mixed vs Full Chimerism to Potentiate GVL Effects After Bone-Marrow TransplantationMarkus Y. Mapara and Megan SykesApplication of Donor Lymphocytes Expressing a Suicide Gene for Early GVL Induction and Later Control of GVH Reactions After Bone-Marrow TransplantationAttilio Bondanza, Fabio Ciceri, and Chiara BoniniIndex

Editorial Reviews

"...a comprehensive and authoritative collection of currently used protocols for adoptive immunotherapy in both pre-clinical and clinical settings." - Immunology News"...will be not only useful for basic researchers but also clinical scientists aiming to translate basic research to a clinical setting." - Immunology and Cell Biology