Adult Neurogenesis 2

Hardcover | January 29, 2011

byGerd Kempermann

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The discovery of adult neurogenesis and of stem cells in the adult brain has changed our view of the mature brain. With new neurons being produced lifelong, brain development does not seem to end and brain plasticity gains a whole different meaning, if the brain's malleability goes beyondsynapses and neurites. But adult neurogenesis occurs in two privileged regions only, the hippocampus and the olfactory system. Since the mid-1990s, the field of adult neurogenesis research has literally exploded. The second edition became necessary, after hundreds of new reports had been published. Most progress has been made with respect to the question of the functional relevance of the new neurons and their contributionto learning and memory. The book has become a reference resource for everybody interested in adult neurogenesis and stem cell biology of the adult brain. It begins with the historical background and describes in detail adult neurogenesis in the hippocampus as well as the subventricular zone and olfactory bulb. Regulatorymechanisms are discussed in great detail. The subject of neurogenesis outside the "canonical" neurogenic regions of rodents and primates is discussed and an entire chapter is dedicated to adult neurogenesis in different species. The book concludes with a chapter on the provocative hypotheses thatlink failing adult neurogenesis with diseases such as temporal lobe epilepsy, major depression, schizophrenia, brain tumors, and dementias.

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The discovery of adult neurogenesis and of stem cells in the adult brain has changed our view of the mature brain. With new neurons being produced lifelong, brain development does not seem to end and brain plasticity gains a whole different meaning, if the brain's malleability goes beyondsynapses and neurites. But adult neurogenesis oc...

Gerd Kempermann is Professor at the CRTD, Center for Regenerative Therapies Dresden, and Speaker of the Dresden site of the DZNE, the German Center for Neurodegenerative disease. He works on the question of how genes and activity regulate adult neurogenesis and what the function of new neurons in the adult brain is.
Format:HardcoverDimensions:616 pages, 10 × 7 × 0.98 inPublished:January 29, 2011Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199729697

ISBN - 13:9780199729692

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Table of Contents

1. Introduction2. History3. Neural Stem Cells4. Neuronal Development5. Neurogenesis in the Adult Subventricular Zone and Olfactory Bulb6. Adult Hippocampal Neurogenesis7. Technical Notes8. Neurogenic and Non-neurogenic Regions9. Regulation10. Function11. Adult Neurogenesis in Different Animal Species12. MedicineIndex