Advances in Bioactivation Research by Adnan ElfarraAdvances in Bioactivation Research by Adnan Elfarra

Advances in Bioactivation Research

EditorAdnan Elfarra

Hardcover | September 19, 2008

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This volume provides researchers with recent information on bioactivation reactions of drugs and toxicants. It also provides examples of how molecular and genomic biology, proteomics, mass spectrometry, and computational modeling are used in bioactivation research. In other sections, focus is on recent applications of bioactivation research in pharmacology, toxicology, and environmental health sciences, where contributors demonstrate the integration of bioactivation research.
Dr. Elfarra received his B.S. degree in Pharmacy at Cairo University, Cairo, Egypt, in 1975 and his Ph.D. degree in Medicinal Chemistry at the University of Minnesota, Minneapolis, MN, in 1983. In 1985, Dr. Elfarra joined Shell Development Company in Houston, Texas as an associate research toxicologist after he completed his postdoctor...
Title:Advances in Bioactivation ResearchFormat:HardcoverDimensions:448 pagesPublished:September 19, 2008Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387772995

ISBN - 13:9780387772998

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Table of Contents

General Concepts and Basic Mechanisms.- Metabolic Concerns in Drug Design.- Role of Bioactivation in Idiosyncratic Drug Toxicity.- Michael Addition-Elimination Reactions.- Induction of Drug Metabolizing Enzymes.- Mechanism-Based Inactivation of Cytochrome P450 2A and 2B Enzymes.- CYP2E1-Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury.- One and Two Electron Mediated Reduction of Quinones.- Lipoxidation-Derived Electrophiles as Biological Reactive Intermediates.- Bioactivation and Protein Modification Reactions of Unsaturated Aldehydes.- TISSUE-Specific Features And Risk Assessment Applications.- Adaptive Responses and Signal Transduction Pathways in Chemically Induced Mitochondrial Dysfunction and Cell Death.- Hepatic Bioactivation and Drug-Induced Liver Injury.- Role of Cysteine S-Conjugate ß-Lyases in the Bioactivation of Renal Toxicants.- Bioactivation of Xenobiotics in Lung: Role of CYPs and FMOs.- Generation of Reactive Metabolites and Associated DNA Adducts from Benzene, Butadiene, and Polycyclic Aromatic Hydrocarbons in Bone Marrow.- Butadiene-Mediated Mutagenesis and Carcinogenesis.- Pharmacogenetics of Drug Bioactivation Pathways.- Human Phenanthrene Metabolites as Probes for the Metabolic Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons.