Volume 75 of Advances in Cancer Research continues the series' goal of publishing timely and authoritative reviews in the broad field of cancer research. Graves and Petersen begin the volume with a review of ets proteins and their role in biological specificity. Chapter 2 by Boshoff and Weiss discusses Kaposi's sarcoma and its associated herpesviruses. Chapter 3 by Taipale and colleagues discusses the ways in which the effects of TGF-B can be targeted through its deposition to the extracellular matrix in a latent form. Petersen and colleagues present their research on breast cancer from the phenotypic differentiation standpoint in Chapter 4. The clinical, pathological, and genetic characteristics of hereditary renal carcinoma are reviewed by Zbar and Lerman in Chapter 5. In Chapter 6, Ellem and co-workers discuss the numerous ways in which metastatic cells escape immune killing. Chapter 7 by Kramer et al. Concludes the volume with a discussion on the role of apoptosis via CD95 in liver, colon, and hematopoetic cells.