Aging of the Genome: the dual role of DNA in life and death

Paperback | April 5, 2007

byJan Vijg

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Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept ofgenomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a lookahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understandingmore about the underlying biology of aging, driven by continuing demographic change.

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Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept ofgenomic instability as a possible universal ...

Jan Vijg is Professor at the Buck Institute for Age Research in Novato, California, USA

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Format:PaperbackDimensions:384 pages, 9.69 × 7.44 × 0.79 inPublished:April 5, 2007Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198569238

ISBN - 13:9780198569237

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Table of Contents

Preface1. Introduction2. The Logic of Aging3. Genome Structure and Function4. Genome Maintenance5. Genome Instability and Accelerated Aging6. The Aging Genome7. From Genome to Phenome8. A Genomic Limit to Life?References and GlossaryLiterature References