Allergy and Allergic Diseases: The New Mechanisms and Therapeutics by Judah A. DenburgAllergy and Allergic Diseases: The New Mechanisms and Therapeutics by Judah A. Denburg

Allergy and Allergic Diseases: The New Mechanisms and Therapeutics

EditorJudah A. Denburg

Paperback | November 5, 2010

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Leading international researchers and clinicians review the latest findings on the cellular and molecular foundations of allergic diseases, particularly those of the airway, skin, and bowel. The key topics treated span the range from epidemiology and the mechanisms of inflammation, to signaling in pathogenesis and allergic reactions. Each contributor treats the pathophysiology of allergy in various organ-based diseases and syndromes, emphasizing important new findings from cellular and molecular biology that illuminate these diseases, but also reveal important leads for the development of novel drugs and therapeutic strategies. Its up-to-date, clinically relevant approach will establish the book as the new standard knowledge base- not only for specialists in clinical immunology and allergy, but also for internists seeking a deeper understanding of the allergic diseases they treat, for scientists studying the cellular and molecular biology of inflammation and immunity, and for researchers focused on drug discovery and therapeutics.
Title:Allergy and Allergic Diseases: The New Mechanisms and TherapeuticsFormat:PaperbackDimensions:615 pages, 10 × 7.01 × 0 inPublished:November 5, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617370266

ISBN - 13:9781617370267

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Table of Contents

Part I. Epidemiology/IGE. Molecular Mechanisms of Isotype Switching to IGE, Donata Vercelli. Cytokines and IGE Regulation, Juha Punnonen and Jan E. de Vries. Environmental Allergens, Thomas A. E. Platts-Mills, Judith A. Woodfolk, and Lisa M. Wheatley. Ontogeny of Allergy, Bengt Bjorksten. Part II. Inflammation: Cellular Aspects. The Role of the Bone Marrow in Allergic Disease, Mark D. Inman, Roma Sehmi, Paul M. O'Byrne, and Judah A. Denburg. The Role of Mast Cells in Inflammation and Homeostasis, Angus J. MacDonald, Fiona L. Wills, Tong-Jun Lin, and A. Dean Befus. Human Langerhans Cells, Thomas Bieber. Eosinophils, Redwan Moqbel and Paige Lacy. Role of Basophils in Allergic Reactions, Peter Valent. Neurogenic Inflammation in Allergic Disease, Peter J. Barnes. Inflammation: Th1/Th2 Cells, Sergio Romagnani. T-Cells in the Pathogenesis of Asthma and Allergic Diseases, Marc Humbert and Stephen R. Durham. Role of CD8+ T-Cells in the Regulation of Immunoglobulin E, Paul A. MacAry and David M. Kemeny. Airway Wall Structure, Peter K. Jeffery, Mariusz J. Gizycki, and Andrew V. Rogers. Epithelium, Mary H. Perdue and Derek M. McKay. Part III. Inflammation: Molecular Aspects. Proinflammatory Cytokines in Allergic Disease, Daniel L. Hamilos. Hemopoietic Cytokines: Function, Receptor, and Signal Transduction, Hirokazu Kurata and Ken-ichi Arai. Adhesion Receptors in Allergic Disease, Andrew J. Wardlaw. Cell/Cytokine Interactions, David H. Broide. Signaling in Mast Cells, Anthony P. Sampson and Martin K. Church. Signaling in Human Basophils, Donald MacGlashan, Jr. Eosinophil Signal Transduction, Hirohita Kita. Part IV. Pathogenesis. Pathogenesis of Allergic Rhinitis, Niels Mygind and Ronald Dahl. Pathogenetic Mechanisms of Urticaria, Allen P. Kaplan. Atopic Eczema, Johannes Ring, Ulf Darsow, and Dietrich Abeck. Pathogenesis of Asthma, Paul M. O'Byrne. Pathogenesis of Allergic Conjunctivitis, Sergio Bonini and Stefano Bonini. Part V. Therapeutics. Glucocorticoids (Corticosteroids), Christopher J. Corrigan. ß-Agonists, Harold S. Nelson. Sodium Cromglycate and Nedocromil Sodium, Alan M. Edwards, Alexis E. Harper, Ken Rainey, and Alan A. Norris. Airway Remodeling and Repair, Peter M. Hockey, Ratko Djukanovic, William R. Roche, and Stephen T. Holgate. Index.

Editorial Reviews

"The book presents a broad overview of the field at a level that is easy to understand. . .provides an advanced understanding of the current state of the field and leaves the reader receptive to new concepts and therapies for allergic disease that will soon be forthcoming"-Dale T. Umetsu, MD, PhD, review in the April 29, 1999 issue of The New England Journal of Medicine"...an excellent book on allergy and allergic diseases....a carefully thought-out whole, starting with IgE mechanisms, environmental allergens, and the new "jungle hypothesis" of atopic disorders beginning in early childhood. The book then proceeds to cellular and molecular aspects of inflammation, highlighting the key points of the pathogenesis of allergy in different organs, and ending with the essentials of treatment." - Allergy"The book certainly has the five main features described in the presentation: it is written by leading authorities in allergy research...it provides an updated comprehensive survey of the mechanisms of allergic diseases; it illustrates the cellular and molecular bases of allergy and asthma; it emphasizes pathogenesis and the relevance of mechanisms to clinical expression; it includes useful information on therapeutics and possibilities for drug discovery." - EACCI