Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols by Erik D. RobersonAlzheimer's Disease and Frontotemporal Dementia: Methods and Protocols by Erik D. Roberson

Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols

byErik D. Roberson

Hardcover | October 25, 2010

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Alzheimer''s disease and frontotemporal dementia, two of the most prevalent neurodegenerative diseases, are dreaded disorders that attack the neural networks underlying memory and personality, systems that make us who we are. Major breakthroughs in recent years have spurred new research approaches to these conditions. In Alzheimer''s Disease and Frontotemporal Dementia: Methods and Protocols, expert investigators bring together the many divergent areas of expertise used to study these diseases, including behavior, electrophysiology, confocal microscopy, and hardcore biochemistry. Beginning with an overview of the two diseases and contemporary research on them, the book continues with specialized protocols for working with amyloid-β peptide, tau, and apolipoprotein E as well as experimental systems for studying AD and FTD, including cell and animal models, and outcome measures that can be used to assess neuronal function in these systems. Written in the highly successful Methods in Molecular Biology''¢ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Alzheimer''s Disease and Frontotemporal Dementia: Methods and Protocols serves as an ideal guide for all scientists pursuing the cause and cure of these widespread and nightmarishly debilitating disorders.
Title:Alzheimer's Disease and Frontotemporal Dementia: Methods and ProtocolsFormat:HardcoverProduct dimensions:277 pages, 25.4 X 17.8 X 0 inShipping dimensions:277 pages, 25.4 X 17.8 X 0 inPublished:October 25, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1607617439

ISBN - 13:9781607617433

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Table of Contents

1. Contemporary Approaches to Alzheimer''s Disease and Frontotemporal Dementia Erik D. Roberson Part I: Working with AD- and FTD-Related Molecules 2. Preparing Synthetic A in Different Aggregation States W. Blaine Stine, Lisa Jungbauer, Chunjiang Yu, and Mary Jo LaDu 3. Isolation of Low-n Amyloid β-Protein Oligomers from Cultured Cells, CSF, and Brain Ganesh M. Shankar, Alfred T. Welzel, Jessica M. McDonald, Dennis J. Selkoe, and Dominic M. Walsh 4. Detecting A *56 Oligomers in Brain Tissues Mathew A. Sherman and Sylvain E. Lesné 5. Assessing A Aggregation State by Atomic Force Microscopy Justin Legleiter 6. Measuring APP Carboxy-Terminal Fragments Luke A. Esposito 7. Detection of APP Intracellular Domain (AICD) in Brain Tissue Sanjay W. Pimplikar and Anupama Suryanarayana 8. Cell-Based Assays for Regulators of Tau Biology Umesh K. Jinwal and Chad A. Dickey 9. Split GFP Complementation Assay for Quantitative Measurement of Tau Aggregation In situ Wanjoo Chun, Geoffrey S. Waldo, and Gail V.W. Johnson 10. Apolipoprotein E Expression and Purification Yvonne Newhouse and Karl H. Weisgraber Part II: Model Systems and Outcome Measures 11. Aβ Toxicity in Primary Cultured Neurons Adriana Ferreira, Roxana C. Sinjoanu, Alexandra Nicholson, and Sara Kleinschmidt 12. Manipulation of Gene Expression in the Central Nervous System with Lentiviral Vectors Binggui Sun and Li Gan 13. Selecting a Mouse Model of Alzheimer''s Disease Jeannie Chin 14. Monitoring Spatial Learning and Memory in Alzheimer''s Disease Mouse Models Using the Morris Water Maze Kimberly Scearce-Levie 15. Step-by-Step In Situ Hybridization Method for Localizing Gene Expression Changes in the Brain Jorge J. Palop, Erik D. Roberson, and Inma Cobos 16. Real-Time Visualization of Axonal Transport in Neurons Yasuko Osakada and Bianxiao Cui 17. Quantifying Biomarkers of Cognitive Dysfunction and Neuronal Network Hyperexcitability in Mouse Models of Alzheimer''s Disease: Depletion of Calcium-Dependent Proteins and Inhibitory Hippocampal Remodeling Jorge J. Palop, Lennart Mucke, and Erik D. Roberson 18. Epigenetic Changes in the Brain: Measuring Global Histone Modifications Gavin Rumbaugh and Courtney A. Miller

Editorial Reviews

From the reviews:"This book brings together research authorities in the field of Alzheimer''s disease (AD) and frontotemporal dementia (FTD) to share their laboratory methods and protocols for molecular and model systems and outcome research in the field of neurodegenerative biomedical research. . The audience includes all laboratory scientists interested in molecular and neuroscience research that seeks a cause and cure for these two devastating disorders. . The book is thoughtfully written and will have the greatest appeal for those with a familiarity with laboratory research methods." (Charlene Hoffman Snyder, Doody''s Review Service, February, 2011)"This is a collection of relatively modern methodologies, focused primarily on the study of amyloid-? processing . . Research technicians will find the ''notes'' sections particularly valuable . . provides a nice reference for anyone interested in studying putative models of Alzheimer''s disease. . Overall, the book is well organized, well written, appropriately succinct, and exceedingly useful in those areas that are addressed, and provides a valuable reference to the basic scientist studying Alzheimer''s disease." (Rudy J. Castellani, Journal of Alzheimer''s Disease, Vol. 25, 2011)