An Introduction to Drug Synthesis

Paperback | February 19, 2015

byGraham Patrick

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An Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development. Written by an experienced and talented author to complement his existing An Introduction to Medicinal Chemistry, the book illustrates how organic synthesis makes important contributions throughout the drug design and discovery process - from the generation of novel drug structures to the improvedefficiency of large scale synthesis.Avoiding excessively detailed descriptions of the underlying synthetic pathways, the book focuses on how synthesis can be used in a strategic way - how and why different synthetic approaches are adopted, and the pros and cons of each. With examples used extensively to illustrate the concepts presented, An Introduction to Drug Synthesis is the ideal resource for any pharmaceutical or medicinal chemistry student who needs a thorough understanding of how the concepts of organic synthesis are applied to the development of therapeuticdrugs. Online Resource CentreAn Introduction to Drug Synthesis is supported by an Online Resource Centre featuring: For registered adopters:* Figures from the book in electronic format; For students:* A suite of multiple-choice questions to support the learning process;* Additional case studies* More detailed descriptions of key synthetic reactions, as a source of further reference.

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From the Publisher

An Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development. Written by an experienced and talented author to complement his existing An Introduction to Medicinal Chemistry, the book illustrates how organic synthesis makes important contributions throughout the d...

Graham Patrick is a lecturer in Organic Chemistry and Medicinal Chemistry at the University of the West of Scotland, Glasgow. He is the author of four other undergraduate textbooks covering medicinal chemistry and organic chemistry, including Introduction to Medicinal Chemistry, which is now in its fifth edition.

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Format:PaperbackDimensions:592 pages, 10.43 × 7.68 × 0.01 inPublished:February 19, 2015Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198708432

ISBN - 13:9780198708438

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Table of Contents

PART A: General synthetic principles1. The role of synthesis in drug discovery2. Drug synthesis3. Retrosynthesis4. Cyclic systems in drug synthesis5. The synthesis of chiral drugs6. Combinatorial and parallel synthesisPART B: Role of synthesis in the drug design and development process7. Synthesis of Lead Compounds8. Analogue Synthesis in Drug Design9. Synthesis of natural products and their analogues10. Chemical and process development11. Synthesis of isotopically labelled compoundsPART C: Synthesis of Selected Antibacterial Agents12. Tetracyclines13. Erythromycin and macrolide antibacterial agents14. Quinolones and fluoroquinolones

Editorial Reviews

"The author has done a great job; it puts the context with the reaction, and fills a genuine gap in the market." --Dr John Spencer, University of Sussex