An Introduction to Medicinal Chemistry

Paperback | January 18, 2013

byGraham L. Patrick

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An Introduction to Medicinal Chemistry is the leading text for university courses on this subject. Renowned for being a textbook loved equally by both students and lecturers, it presents complete coverage in an accessible and engaging style. The text begins with the essential biochemistry on which an understanding of medicinal chemistry is built, introducing the structure and function of important drug targets. It then explores how drugs interact with the body and the consequences of those reactions. There is a section on generalprinciples and strategies involved in discovering and designing new drugs, and another on useful "tools of the trade". The text ends with a contemporary look at specific topics within medicinal chemistry, for example, antiviral and anticancer agents; cholinergics and anticholinesterases; andantiulcer agents.Learning features throughout help to unlock this fascinating subject. A glossary helps to familiarize the language of medicinal chemistry. Boxes present in-depth material and explore how concepts are applied in practice. Key points summarise sections within chapters, providing a basis for revision,and questions at the end of chapters and on the accompanying Online Resource Centre allow the reader to test their understanding and develop molecular modelling skills.

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From the Publisher

An Introduction to Medicinal Chemistry is the leading text for university courses on this subject. Renowned for being a textbook loved equally by both students and lecturers, it presents complete coverage in an accessible and engaging style. The text begins with the essential biochemistry on which an understanding of medicinal chemistr...

Dr. Graham Patrick gained his BSc Honours at Glasgow University, winning the McKay-Smith Prize for Chemistry. He completed his PhD with Professor Kirby and Professor Robins studying the biosynthesis of gliotoxin and related fungal metabolites. Following this, he worked in the pharmaceutical industry as a research chemist and radiochemi...

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Format:PaperbackDimensions:848 pagesPublished:January 18, 2013Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199697396

ISBN - 13:9780199697397

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Table of Contents

1. Drugs and drug targets - an overviewPART A Drug targets- structure and function2. Protein structure and function3. Enzymes: structure and function4. Receptors: structure and function5. Receptors and signal transduction6. Nucleic acids: structure and functionPART B Pharmacodynamics and pharmacokinetics7. Enzymes as drug targets8. Receptors as drug targets9. Nucleic acids as drug targets10. Miscellaneous drug targets11. Pharmacokinetics and related topicsCase study 1: StatinsPART C Drug discovery, design, and development12. Drug discovery: finding a lead13. Drug design: optimizing target interactions14. Drug design: optimizing access to the target15. Getting the drug to marketCase study 2: The design of ACE inhibitorsCase study 3: Artemisinin and related antimalarial drugsCase study 4 : The design of oxamniquinePART D Tools of the trade16. Combinatorial synthesis17. Computers in medicinal chemistry18. Quantitative structure-activity relationships (QSAR)Case study 5: De novo design of a thymidylate synthase inhibitorPART E Selected topics in medicinal chemistry19. Antibacterial agents20. Antiviral agents21. Anticancer agents22. Cholinergics, anticholinergics, and anticholinesterases23. Drugs acting on the adrenergic nervous system24. Opioid analgesics25. Antiulcer agentsCase study 6: Steroidal anti-inflammatory agentsCase Study 7: Design of a novel antidepressantAppendices

Editorial Reviews

"Patrick's book is excellent. I always get good feedback from my students who find it informative, interesting, and readable." --Dr Alison Hill, University of Exeter