An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2 by Joachim JoseAn Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2 by Joachim Jose

An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on…

Guest editorJoachim Jose, Marc Le Borgne, Lorenzo A. Pinna

Paperback | May 22, 2017

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The 8th International Conference on Protein Kinase CK2 (www.uks.eu/ck2), organized by Matthias Montenarh and Claudia Götz, will be held at the Faculty of Medicine of Saarland University, in Homburg, Germany, from 6–9 September, 2016.
Protein kinase CK2 is a serine/threonine kinase, which is highly conserved in evolution. Knock-out experiments have shown that this enzyme is absolutely necessary for cell viability. The enzyme is highly expressed in rapidly proliferating cells, which goes along with an elevated enzyme activity. Protein kinase CK2 is involved in a broad range of signaling pathways, regulating proliferation, differentiation, apoptosis, or senescence. Recent advances towards the characterization of the three-dimensional structure of protein kinase CK2 and its subunits will undoubtedly yield important new insights into its regulation, and the functions of CK2. Moreover, with two inhibitors of the enzyme presently in clinical phase II trials, human protein kinase CK2 has appeared as an emerging target for cancer diseases.

Title:An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on…Format:PaperbackProduct dimensions:320 pages, 9.61 × 6.69 × 0.87 inShipping dimensions:9.61 × 6.69 × 0.87 inPublished:May 22, 2017Publisher:MDPI AGLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3038424129

ISBN - 13:9783038424123

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Table of Contents

1) Exploring the CK2 Paradox: Restless, Dangerous, Dispensable
2) Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks
3) The New Role for an Old Kinase: Protein Kinase CK2 Regulates Metal Ion Transport
4) CK2—An Emerging Target for Neurological and Psychiatric Disorders
5) CK2 in Cancer: Cellular and Biochemical Mechanisms and Potential Therapeutic Target
6) CK2 Molecular Targeting—Tumor Cell-Specific Delivery of RNAi in Various Models of Cancer
7) Targeting Protein Kinase CK2: Evaluating CX-4945 Potential for GL261 Glioblastoma Therapy in
Immunocompetent Mice
8) Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs
Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor
9) The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational
Drug Design
10) Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2
Inhibitors and Database Mining
11) D11-Mediated Inhibition of Protein Kinase CK2 Impairs HIF-1????-Mediated Signaling in Human
Glioblastoma Cells
12) Identification of a Potent Allosteric Inhibitor of Human Protein Kinase CK2 by Bacterial Surface
Display Library Screening
13) In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface
14) Drosophila Protein Kinase CK2: Genetics, Regulatory Complexity and Emerging Roles
during Development
15) The Link between Protein Kinase CK2 and Atypical Kinase Rio1
16) The Phosphorylation of PDX-1 by Protein Kinase CK2 Is Crucial for Its Stability
17) Inhibition of Protein Kinase CK2 Prevents Adipogenic Differentiation of Mesenchymal Stem Cells
Like C3H/10T1/2 Cells
18) Ablation of Protein Kinase CK2???? in Skeletal Muscle Fibers Interferes with Their Oxidative Capacity