Animal Models of Brain Tumors by Ricardo Martínez MurilloAnimal Models of Brain Tumors by Ricardo Martínez Murillo

Animal Models of Brain Tumors

EditorRicardo Martínez Murillo, Alfredo Martínez

Hardcover | November 5, 2012

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Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis.  Animal Models of Brain Tumors brings together developments and discoveries in "in vivo" experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors,  therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism.  Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results. Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.
Title:Animal Models of Brain TumorsFormat:HardcoverDimensions:404 pagesPublished:November 5, 2012Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1627032088

ISBN - 13:9781627032087

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Table of Contents

Part I: IntroductionBrain Tumor Models to Predict Clinical Outcome: Like the Phoenix?            Lois A. Lampson Animal Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints            José M. Orellana-Muriana Part II: Animal Models Offer Insights into Human Brain Neoplasms The VM Mouse Model of Glioblastoma Multiforme            Thomas N. Seyfried, Laura M. Shelton, and Leanne C. Huysentruyt Oligodendroglioma Models            Nanna Lindberg and Lene Uhrbom Medulloblastoma Model            Jasmine Lau and William A. Weiss Learning about Retinoblastoma from Mouse Models that Missed            David Cobrinik Ependymoma Models            Jesús Vaquero and Mercedes Zurita Meningioma Models            Jessica Rainey and Randy L. Jensen Pituitary Models            Walavan Sivakumar and William T. Couldwell Growth Regulation of Nervous System Tumors: Models for Assessment of Angiogenesis in Brain Tumors            Kelly Burrell, Elena Bogdanovic, Shahrzad Jalali, Gelareh Zadeh, and Abhijit Guha Part III: Cellular, Molecular, and Genetic Basis of Brain Tumors: Data from Animal Models Using Genetically-Engineered Mouse Models to Understand Low-Grade Glioma Development and Growth in Children            Aparna Kaul, Ibrahim Hussain, and David H. Gutmann EGFR and Tumor-Suppressor Function in Brain Cancer Development            Julie Lessard and Al Charest Part IV: Therapies in the Treatment of Malignant Glioma: Data from Animal Models Rodent Glioma Models: Intracranial Stereotactic Allografts and Xenografts            Hikmat Assi, Marianela Candolfi, Pedro R. Lowenstein, and Maria G. Castro Immunotherapy of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models            Kristen A. Batich, Bryan D. Choi, and Duane A. Mitchell Assessing Mechanisms of Glioblastoma Invasion             Stephen M. Robbins and Donna L. Senger Part V: Imaging Technologies in Animal Tumor Models: Measuring Brain Tumor Growth and Metabolism Positron Emission Tomography (PET)-Based Molecular Imaging            Yannic Waerzeggers, Thomas Viel, Sonja Schäfers, Stefan Wagner, Andreas Faust, Burkhard Riemann, Klaus Kopka, Otmar Schober, Klaus Schäfers, and Andreas H. Jacobs In Vivo Magnetic Resonance Spectroscopic Imaging (MRSI) and Ex Vivo Quantitative Neuropathology by High Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy (HRMAS)            Rui V. Simões, Ana Paula Candiota, Margarida Julià-Sapé, and Carles Arús Single Photon Emission Computed Tomography (SPECT) in Small Animal CNS Research            André Constantinesco, Christian Goetz, and Philippe Choquet