Animal Models of Movement Disorders: Volume I by Emma L. LaneAnimal Models of Movement Disorders: Volume I by Emma L. Lane

Animal Models of Movement Disorders: Volume I

EditorEmma L. Lane, Stephen B. Dunnett

Hardcover | September 15, 2011

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Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume I contains general methods of movement disorder assessment as well as an extensive section on dopamine systems.  Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.
Title:Animal Models of Movement Disorders: Volume IFormat:HardcoverDimensions:462 pagesPublished:September 15, 2011Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617792977

ISBN - 13:9781617792977

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Table of Contents

Part I: Generic Methods of Assessment 1. Why Can't a Rodent Be More like a Man?: A Clinical Perspective            Anne E. Rosser 2. Zebrafish as a Vertebrate Model Organism for Studying Movement Disorders            Maria Sundvik and Pertti Panula 3. Methodological Strategies to Evaluate Functional Effectors Related to Parkinson's Disease through Application of C. elegans Models            Kim A. Caldwell and Guy A. Caldwell 4. Effects of Alpha-Synuclein Expression on Behavioral Activity in Drosophila, a Simple Model of Parkinson's Disease            Robert G. Pendleton, Xiaoyun C. Yang, Natalie Jerome, Ornela Dervisha, and Ralph Hillman 5. Neurological Evaluation of Movement Disorders in Mice            Simon Brooks 6. Rodent Skilled Reaching for Modeling Pathological Conditions of the Human Motor System            Jenni M. Karl and Ian Q. Whishaw 7. High Throughput Mouse Phenotyping            Sabine M. Hölter and Lisa Glasl 8. MRI of Neurological Damage in Rats and Mice            Mathias Hoehn 9. Quantification of Brain Function and Neurotransmission System In Vivo by Positron Emission Tomography: A Review of Technical Aspects and Practical Considerations in Preclinical Research            Nadja Van Camp, Yann Bramoullé, and Philippe Hantraye 10. Optical Approaches to Studying the Basal Ganglia            Joshua L. Plotkin, Jaime N. Guzman, Nicholas Schwarz, Geraldine Kress, David L. Wokosin, and D. James Surmeier 11. Electrophysiological Analysis of Movement Disorders in Mice            Shilpa P. Rao, Véronique M. André, Carlos Cepeda, and Michael S. Levine Part II: Dopamine Systems 12. Genetic Models of Parkinson`s Disease            Ralf Kühn, Daniela Vogt-Weisenhorn, and Wolfgang Wurst 13. 6-OHDA Lesion Models of Parkinson's Disease in the Rat            Eduardo M. Torres and Stephen B. Dunnett 14. 6-OHDA Toxin Model in Mouse            Gaynor A. Smith and Andreas Heuer 15. Rotation in the 6-OHDA Lesioned Rat            Stephen B. Dunnett and Eduardo M. Torres 16. Of Rats and Patients: Some Thoughts about Why Rats Turn in Circles and Parkinson's Disease Patients Cannot Move Normally            Gordon W. Arbuthnott 17. Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson's Disease and Stroke            Sheila M. Fleming and Timothy Schallert 18. Rodent Models of L-DOPA-Induced Dyskinesia            Hanna S. Lindgren and Emma L. Lane 19. Using the MPTP Mouse Model to Understand Neuroplasticity: A New Therapeutic Target for Parkinson's Disease?            Giselle M. Petzinger, Beth E. Fisher, Garnik Akopian, Ruth Wood, John P. Walsh, and Michael W. Jakowec 20. The MPTP Treated Primate, with Specific Reference to the Use of the Common Marmoset (C. jacchus)            Michael J. Jackson and Peter Jenner 21. Behavioral Assessment in the African Green Monkey after MPTP Administration            D. Eugene Redmond, Jr.