Annotating New Genes: From In Silico Screening To Experimental Validation by Shizuka UchidaAnnotating New Genes: From In Silico Screening To Experimental Validation by Shizuka Uchida

Annotating New Genes: From In Silico Screening To Experimental Validation

byShizuka UchidaEditorShizuka Uchida

Hardcover | August 6, 2012

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In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases and software available, before moving on to cover programming guidelines, including a specific case study on the use of C-It for in silico screening. The second half of the book offers a step-by-step guide to experimental validation concepts and procedures, as well as an overview of additional potential applications of this approach in the field of stem cells and tissue regeneration, before a concluding chapter summarises the concepts and theories presented.

  • Focuses not only on screening but also on biological validations
  • Provides details of databases and software (web interface) products for biologists with minimal computation skills
  • Offers a step-by-step outline of the procedure involved
Shizuka Uchidais a group leader in the Max-Planck Institute for Heart and Lung Research in Bad Nauheim, Germany. He is a trained bioinformatician and a developmental biologist with a specific focus on adult stem cell research, and has extensive experience in combining the power of computers and data mining methods with state-of-the-art...
Title:Annotating New Genes: From In Silico Screening To Experimental ValidationFormat:HardcoverDimensions:196 pages, 9.21 × 6.14 × 0.5 inPublished:August 6, 2012Publisher:Woodhead PublishingLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1907568689

ISBN - 13:9781907568688

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Table of Contents

Databases and software to make your research life easier; How to program like a bioinformatician? Case study: C-It, knowledge database for screening evolutionarily conserved, tissue-enriched, uncharacterized genes; Experimental validation: concepts and practice; Further application: Adult stem cells and tissue regenerations; Conclusion