Annual Reports in Combinatorial Chemistry and Molecular Diversity by M.R. PaviaAnnual Reports in Combinatorial Chemistry and Molecular Diversity by M.R. Pavia

Annual Reports in Combinatorial Chemistry and Molecular Diversity

EditorM.R. Pavia, W.H. Moos

Paperback | December 6, 2010

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Combinatorial chemistry and molecular diversity approaches to scientific and novel product R & D have exploded in the 1990s. For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. The second volume in this series includes contributions on methods, solid phases, purification, analysis, carbohydrates, patent strategies and tactics, diversity profiling and combinatorial series design, and finishes with a survey of chemical libraries yielding biologically active agents and a compendium of solid phase chemistry publications. Each contribution is prepared by a recognized expert resulting in a high quality account of the recent advances in the field.
Title:Annual Reports in Combinatorial Chemistry and Molecular DiversityFormat:PaperbackDimensions:178 pages, 10 × 7.01 × 0 inPublished:December 6, 2010Publisher:Springer NetherlandsLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9048152275

ISBN - 13:9789048152278

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Table of Contents

Preface. Introduction; M.R. Pavia, W.H. Moos. Solution-phase combinatorial chemistry; D.M. Coe, C. Storer. New developments in solid phase synthesis; I. Sucholeiki. Recent advances in solid phase synthesis; S.E. Hall. Purification of combinatorial libraries; H.N. Weller. Analytical methods for quality control of combinatorial libraries; W.L. Fitch. Accessing Carbohydrate-based combinatorial libraries through solid phase and solution phase approaches; M.J. Sofia. Patent Strategies in molecular diversity; G.D. Green. Patent tactics in molecular diversity: Things that get around, come around; K. Bozicevic. Advances in diversity profiling and combinatorial series design; D.K. Agrafiotis, et al. Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997; R.E. Dolle. Compendium of solid phase chemistry publications; I.W. James. Author Index. Subject Index.