Antibody Engineering: A Practical Approach by John McCafferty

Antibody Engineering: A Practical Approach

EditorJohn McCafferty, Hennie Hoogenboom, Dave Chiswell

Paperback | November 1, 1980

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Recombinant DNA techniques have revolutionized the isolation and production of antibodies in recent years, and rapid changes have been made. This new Practical Approach book details protocols which allow the researcher to isolate a new antibody, analyse its properties, format the rightantibody molecule or fragment, and produce it in usable quantities.

About The Author

John McCafferty, Hennie Hoogenboom, and David J. Chiswell are all at Cambridge Antibody Technology Limited.

Details & Specs

Title:Antibody Engineering: A Practical ApproachFormat:PaperbackDimensions:348 pages, 9.21 × 6.14 × 0.75 inPublished:November 1, 1980Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0199635927

ISBN - 13:9780199635924

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Table of Contents

1. Construction and use of antibody gene repertoires2. Affinity maturation of antibodies using phage display3. Human antibody repertoires in transgenic mice: manupulation and transfer of YACs4. Measuring antibody affinities in solution5. Measuring antibody affinities using Bio-sensors6. Analysis of human antibody sequences7. Rodent to human antibodies by CDR grafting8. Rodent to human antibodies by phage display9. Choosing and manipulating effector functions10. Secretion and purification of antibody fragments expressed in bacteria11. Production of single chain Fv monomers and multimers12. Expression of immunoglobulin genes in mammalian cells13. In vitro linkage of antibody fragments into dimeric and multimeric forms

Editorial Reviews

`This book is very useful for practising antibody engineers, providing extra information that enables them to adopt new techniques or expand into new areas. ... this is a useful and interesting resource for practising antibody engineers and I will make sure my students have access to it.'SGM Quarterly, August 1997