Antibody Fc: : Linking Adaptive And Innate Immunity

Hardcover | September 20, 2013

byMargaret AckermanEditorFalk Nimmerjahn

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Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system

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From the Publisher

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This vo...

From the Jacket

Antibodies represent the correlate of protection for numerous vaccines, and are the most rapidly growing class of drugs, representing a tremendous economic and therapeutic sector ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for anti...

Margaret E. Ackerman studied molecular engineering at the Massachusetts Institute of Technology under K. Dane Wittrup, followed by postdoctoral studies at the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University under Galit Alter. She was appointed an Assistant Professor of En...
Format:HardcoverDimensions:358 pages, 9.25 × 7.5 × 0.98 inPublished:September 20, 2013Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123948029

ISBN - 13:9780123948021

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Table of Contents

Part 1: Effector Mechanisms Ch 1: Antibody Dependent Cellular Cytotoxicity Ch 2: Antibody-Dependent Cellular Phagocytosis and its Impact on Pathogen Control Ch 3: Interactions between the Complement System and Fc³ Receptors

Part 2: Effector Cells Ch 4: Natural Killer Cells Ch 5: Phagocytes and Immunoglobulins Ch 6: B Cells

Part 3: FcR Ch 7: Structural Recognition of Immunoglobulins by Fcg Receptors Ch 8: Fc³ Rs Across Species Part 4: Variability of the Fc Domain Ch 9: Human IgG Subclasses Ch 10: Antibody Glycosylation

Part 5: Genetic Associations Ch 11: Activating and Inhibitory Fc³ Rs in Autoimmune Disorders Ch 12: Fcg Receptor Polymorphisms and Susceptibility to Infection Ch 13: Role of IgG Fc Receptors in Monoclonal Antibody Therapy of Cancer

Part 6: Evolving areas Ch 14: Interactions Among Monoclonal Antibody Mechanisms of Action Ch 15: Fc Receptor-Dependent Immunity Ch 16: Fc³ Receptors as Therapeutic Targets Ch 17: Fc Protein Engineering Ch 18: Bacterial Modulation of Fc Effector Functions Ch 19: Pathogenic Exploitation of Fc Activity Ch 20: Mechanisms of Immunoglobulin-Mediated Mucus Entrapment of Pathogens at Various Mucosal Surfaces

Editorial Reviews

".highly recommended reading for all students of immunology and scientists involved in the research and development of therapeutic antibodies and vaccines because of its comprehensive coverage of relevant topics.also recommended as an excellent resource for academic, government and company libraries."--mAbs, May/June 2014 "Antibody Fc: Linking Adaptive and Innate Immunity is highly recommended reading for all students of immunology and scientists involved in the research and development of therapeutic antibodies and vaccines because of its comprehensive coverage of relevant topics.The book is also recommended as an excellent resource for academic, government and company libraries."--mAbs, March 21, 2014 "Ackerman and Nimmerjahn offer this volume on the immunological functions of the Fc antibody region. The first two parts discuss effector mechanisms and their mediating cells including antibody-dependent cytotoxicity, the complement system, phagocytosis, natural killer and B cells. Parts III-IV cover general properties of Fc immune receptors, receptor variation amongst species, and the structural variations and glycoside modifications of the Fc domain."--ProtoView.com, February 2014