Anticancer Treatments And Cardiotoxicity: Mechanisms, Diagnostic And Therapeutic Interventions

Hardcover | December 6, 2016

byPatrizio LancellottiEditorJose L Zamorano, Maurizio Galderisi

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Anticancer Treatments and Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions presents cutting edge research on the adverse cardiac effects of both radiotherapy and chemotherapy, brought together by leaders in the field. Cancer treatment-related cardiotoxicity is the leading cause of treatment-associated mortality in cancer survivors and is one of the most common post-treatment issues among survivors of adult cancer. Early detection of the patients prone to developing cardiotoxicity, taking in to account the type of treatment, history and other risk factors, is essential in the fight to decrease cardiotoxic mortality. This illustrated reference describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment. In addition, new guidelines on imaging for the screening and monitoring of these patients are also presented. Anticancer Treatments and Cardiotoxicity is an essential reference for those involved in the research and treatment of cardiovascular toxicity. Provides algorithms essential for the use of imaging, and biomarkers for the screening and monitoring of patients Written by world-leading experts in the field of cardiotoxicity Includes high-quality images, case studies, and test questions Describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment

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Anticancer Treatments and Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions presents cutting edge research on the adverse cardiac effects of both radiotherapy and chemotherapy, brought together by leaders in the field. Cancer treatment-related cardiotoxicity is the leading cause of treatment-associated mortality in c...

Patricio Lancellotti is head of the intensive care cardiology unit at the University of Liège Hospital Center and Professor of Clinical Medicine at the University of Liège. His research, conducted at Professor Luc Piérard's department of cardiology, has led to significant progress in the care of patients suffering from functional mitra...

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Format:HardcoverDimensions:470 pages, 9.41 × 7.24 × 0.98 inPublished:December 6, 2016Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128025093

ISBN - 13:9780128025093

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Table of Contents

Section I: General Considerations

Chapter 1. Epidemiology and Trend of Prognosis in Cancer Patients

Chapter 2. Categories of Anticancer Treatments

Chapter 3. Classification by Mechanisms of Cardiotoxicity

Chapter 4. Cardiotoxicity of Oncologic Treatments: Is There a Uniform Definition?

Chapter 5. The Impact of Radiotherapy

Section II: Detrimental Effects of Anticancer Drugs and Radiotherapy on the Heart

Chapter 6. Lessons From Preclinical Models

Chapter 7. Genetic and Epigenetic Risk Factors

Chapter 8. Changes of Myocardial Structure and Function

Chapter 9. Alteration of Heart Valves

Chapter 10. Pericardial Damage

Chapter 11. Effects of Radiotherapy on Vessels and Coronary Arteries

Chapter 12. Cardiac Conduction Disturbances

Section III: Cardiovascular Complications of Cancer Treatments

Chapter 13. Cardiac Rhythm Disturbances

Chapter 14. Acute and Chronic Heart Failure

Chapter 15. Coronary Artery Disease

Chapter 16. Pericardial Effusion and Pericarditis

Chapter 17. Radiation-Induced Carotid Atherosclerosis

Chapter 18. Valvular Heart Disease

Chapter 19. Atrial Fibrillation and Stroke in Cancer Patients

Section IV: Imaging Evaluation of Cardiac Structure and Function in Cancer Patients

Chapter 20. The Role of Echocardiography

Chapter 21. The Role of Cardiovascular Magnetic Resonance (CMR)

Chapter 22. Nuclear Medicine Imaging and Cardiotoxicity

Section V: Detection of Cardiac Dysfunction and Predictors of Cardiotoxicity

Chapter 23. Detection by Cardiac Imaging: LV Ejection Fraction, Diastolic Dysfunction, Tissue Doppler, and Speckle Tracking Echocardiography

Chapter 24. The Role of Biomarkers: Troponins, BNP, MPO, and Other Biomarkers

Chapter 25. Screening and Comprehensive Follow-Up Evaluation

Chapter 26. Preoperative Assessment for Noncardiac Surgery

Section VI: Cardiotoxicity in Childhood

Chapter 27. Cardiotoxicity of Childhood Cancer Treatments

Section VII: Management of Anticancer Drugs Related Cardiotoxicity

Chapter 28. Nonpharmacologic Therapy

Chapter 29. Beta-Blockers

Chapter 30. Angiotensin-Converting Enzyme Inhibition

Chapter 31. Diuretics

Chapter 32. Antiarrhythmic Drugs

Chapter 33. Anticoagulation in Cancer Patients

Chapter 34. New Drugs: The Beneficial Effects of Ranolazine

Chapter 35. Percutaneous Coronary Intervention and Cardiac Surgery in Cancer Patients

Chapter 36. Focus on the Patient With Known Cardiac Disease

Chapter 37. Multidisciplinary Approach to Cardiac Disease in Cancer Patients

Section VIII: Future Research Priorities

Chapter 38. Pharmacogenomics Screening

Chapter 39. Cardiac Monitoring During Clinical Trials

Chapter 40. Preventive Therapy

Chapter 41. Cardiotoxicity: Future Research Directions