Antigenic Variation

Other | August 1, 2003

byCraig, Alister G., Alister G. Craig

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The topic of antigenic variation is important in both biology and medicine. It is of enormous interest, as it describes the process(es) whereby microorganisms 'shift shape', by genetic rearrangement or otherwise. In medical terms, this has a major impact on the infectious disease process, since the immune system has great difficulty in keeping up with this variation, and thus eliminating the infectious agent. Antigenic variation is a major method by which microbes evade the immune response, and persist in the body.
The broad scope of the book appeals to all those working in the field of infectious disease, immunology of infection, pathogenesis, molecular biology and also to evolutionary biologists. Topics covered include not only bacterial species, and viruses such as influenza, HIV, Rotavirus, but also eukaryotic parasites - one of the most fascinating groups of organisms exhibiting this behaviour.

Comprehensive coverage of antigenic variation from viruses to parasites
Discussions devoted to molecular mechanisms of host evasion
Detailed descriptions of host/pathogen interactions

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From the Publisher

The topic of antigenic variation is important in both biology and medicine. It is of enormous interest, as it describes the process(es) whereby microorganisms 'shift shape', by genetic rearrangement or otherwise. In medical terms, this has a major impact on the infectious disease process, since the immune system has great difficulty in...

Format:OtherDimensions:464 pages, 1 × 1 × 1 inPublished:August 1, 2003Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080475884

ISBN - 13:9780080475882

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Table of Contents

Synthesis of allelic/antigenic variation
HIV variation - a question of signal-to-noise
Calicivirus
Influenza, the chameleon virus
Rotaviruses
Mycoplasma
Haemophilus Influenzae
Phase Variation inHelicobacter pyloriLipopolysaccharide
Genetic Variation in the PathogenicNeisseriaSpecies
Candida Albicans
The MSG Gene Family and Antigenic Variation in the Fungus P.carinii
Trypanosome Antigenic Variation - a heavy investment in the evasion of immunity
Antigenic variation inAnaplasma marginale andEhrlichia (Cowdria) ruminantium
Antigenic Variation and its' Significance toBabsesia
Antigenic Variation inPlasmodium falciparumand otherPlasmodium
Species
Antigenic Variation inBorrelia: Relapsing Fever and Lyme Borreliosis
Surface Antigenic Variation inGiardia lamblia
Free-living and Parasitic Ciliates:The Impact of Antigenic Variation on Pathogen Population Structure, Fitness and Dynamics