Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery by Philip J. RosenthalAntimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery by Philip J. Rosenthal

Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery

EditorPhilip J. Rosenthal

Paperback | November 19, 2010

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Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

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Title:Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug DiscoveryFormat:PaperbackDimensions:400 pagesPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617371246

ISBN - 13:9781617371240

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Table of Contents

I. IntroductionThe Need for New Approaches to Antimalarial ChemotherapyPhilip J. Rosenthal and Louis H. MillerThe History of Antimalarial DrugsSteven R. Meshnick and Mary J. DobsonTransport and Trafficking in Plasmodium-Infected Red CellsKasturi Haldar and Thomas AkompongThe Plasmodium Food VacuoleRitu Banerjee and Daniel E. GoldbergClinical and Public Health Implications of Antimalarial Drug ResistancePiero L. Olliaro and Peter B. BlolandII. Established Antimalarial Drugs and Compounds Under Clinical DevelopmentChloroquine and Other Quinoline AntimalarialsLeann Tilley, Paul Loria, and Mick Foley8-AminoquinolinesRalf P. Brueckner, Colin Ohrt, J. Kevin Baird, and Wilbur K. MilhousMechanisms of Quinoline ResistanceGrant Dorsey, David A. Fidock, Thomas E. Wellems, and Philip J. RosenthalFolate Antagonists and Mechanisms of ResistanceChristopher V. PloweArtemisinin and Its DerivativesSteven R. Meshnick. Atovaquone-Proguanil Combination, Akhil B. VaidyaThe Antimalarial Drug Portfolio and Research PipelinePiero L. Olliaro and Wilbur K. MilhousIII. New Compounds, New Approaches, and New TargetsNovel Quinoline AntimalarialsPaul A. Stocks, Kaylene J. Raynes, and Stephen A. WardNew Antimalarial Trioxanes and EndoperoxidesGary H. Posner, Mikhail Krasavin, Michael McCutchen, Poonsakdi Ploypradith, John P. Maxwell, Jeffrey S. Elias, and Michael H. ParkerAntibiotics and the Plasmodial Plastid OrganelleBarbara Clough and R. J. M. (Iain) WilsonFresh Paradigms for Curative AntimetabolitesPradipsinh K. Rathod. Iron Chelators, Mark Loyevsky and Victor R. GordeukProtease InhibitorsPhilip J. RosenthalInhibitors of Phospholipid MetabolismHenri Joseph Vial and Michèle CalasDevelopment of New Malaria Chemotherapy by Utilization of Parasite-Induced TransportAnnette M. Gero and Alexander L. Weis

Editorial Reviews

"With contributions from 41 different authors, this book provides a welcome collection of short reviews covering numerous topics in antimalarial chemotherapy. ...this book will offer a useful review for those who study malaria and, more importantly, an entry point into antimalarial chemotherapy for those new in the field." - Journal of Medicinal Chemistry"...the publication of a new on antimalarial chemotheraphy is very topcial and timely. Philip Rosenthal has put together a very comprehensive book on the current status of research in this important field of medicianl chemistry....The part on established antimalarial drugs covers all drugs currently in clinical application and trials....Special emphasis is put in many articles on aspects of toxicity, therapy, problems, and future developments....the editor has managed to compile the contributions in such a way that a comprehensive picture of the current status emerges and the book feels more like a single-author publication than an edited work....The book is a must for chemists, biologists, and health professionals involved in malaria research." - ChemBioChem"...thought provoking with its new leads to drug discovery...an essential addition to the libraries and an essential reading book for malariologists." -The National Journal of India