Antimicrobial Drugs: Chronicle of a twentieth century medical triumph

Hardcover | March 15, 2008

byDavid Greenwood

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Between 1935 and 1944 the field of microbiology, and by implication medicine as a whole, underwent dramatic advancement. The discovery of the extraordinary antibacterial properties of sulphonamides, penicillin, and streptomycin triggered a frantic hunt for more antimicrobial drugs that was toyield an abundant harvest in a very short space of time. By the early 1960s more than 50 antibacterial agents were available to the prescribing physician and, largely by a process of chemical modification of existing compounds, that number has more than tripled today. We have become so used to theready availability of these relatively safe and highly effective 'miracle drugs' that it is now hard to grasp how they transformed the treatment of infection. This book documents the progress made from the first tentative search for an elusive 'chemotherapy' of infection in the early days of the twentieth century, to the development of effective antiviral agents for the management of HIV as the millennium drew to a close. It also offers a celebration ofthe individuals and groups that made this miracle happen, as well as examining the inexorable rise of the global pharmaceutical industry, and, most intriguingly, the essential input of luck.Infection still maintains a high profile in both medicine and the media, with the current threats of 'superbugs' such as MRSA acquired in hospital, and a potential resistance to antibiotics. This book tracks the history of antimicrobial drugs, a remarkable medical triumph that has provided doctorswith an amazing armoury of safe and effective drugs that ensure that reversion to the helpless state of the fight against infection witnessed in the early 1900s is extremely unlikely. This timely compendium acknowledges the agents that have surely led to the relief of more human and animal sufferingthan any other class of drugs in the history of medical endeavour.

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Between 1935 and 1944 the field of microbiology, and by implication medicine as a whole, underwent dramatic advancement. The discovery of the extraordinary antibacterial properties of sulphonamides, penicillin, and streptomycin triggered a frantic hunt for more antimicrobial drugs that was toyield an abundant harvest in a very short s...

Professor Greenwood was formerly at St Batholomew's Hospital, London before joining the Department of Microbiology at the University of Nottingham Medical School in 1974, where he remained until retirement in 2000. He was Professor of Antimicrobial Science between 1989 and 2000, and is the former Archivist to the British Society for ...

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Format:HardcoverDimensions:408 pages, 9.69 × 6.73 × 1.14 inPublished:March 15, 2008Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199534845

ISBN - 13:9780199534845

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Table of Contents

1. Agents of infection2. Out of darkness3. From quinine to sulphonamides (by way of serendip)4. Wonder drugs5. The taming of tuberculosis and leprosy6. The golden age of pills and profits7. Progress against parasites8. The poor relations: fungi and viruses9. The spectre at the feast

Editorial Reviews

"Enterprises such as this book require huge efforts from the author and pay great dividends to the loyal reader. For the origins of such drugs as avlosulphon and zanamivir, and many in between, this volume is a thorough and entertaining introduction."--British Medical Journal .,."offers a fascinating account. The book has been written with great care and each chapter is extensively referenced...will be of interest to all lecturers, researchers, students, and drug company employees engaged in antibiotic-related teaching and work. Every library should have a copy!"--Society for General Microbiology