Antisense Research and Application by Stanley T. CrookeAntisense Research and Application by Stanley T. Crooke

Antisense Research and Application

EditorStanley T. Crooke

Paperback | October 8, 2012

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Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.
Title:Antisense Research and ApplicationFormat:PaperbackDimensions:656 pagesPublished:October 8, 2012Publisher:Springer Berlin HeidelbergLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642637302

ISBN - 13:9783642637308

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Table of Contents

Basic Principles of Antisense Therapeutics.-Antisense Medicinal Chemistry.-In vitro Cellular Uptake...-Pharmaco- kinetic Properties...-Toxocity of Ligodeoxynucleotide Therapeutic Agents.-Pharmacokinetic Properties of Phosphoro- thiotae Humans.-Safety and Tolerance of Humans.-Immune Stimulation by Oligon.-Pharmacological Inhibition of Dopaminergic and Other Neurotransmitter Receptors. Pharmacological Effects of Antisense Oligon. Inhibition of Immediate Early Response Genes in the DNS. Inhibition of G Proteins by Antisense Drugs.-Use of Antisense Oligon. to Modify Inflammatory Processes.- Antisense Oligon. and Their Anticancer Activities.- Pharmacological Activity of Antisense Animal Models of Disease.-Clinical Antiviral Activities.-Antisense Protein Kinase C-alpha and C-raf Kinase.-Nucleic Acid Therapeutics for Human Leukemia.- Properties of ISIS 2302.-Pharmacokinetics & Bioavailability of Oligon.Following Oral and Colorectal Exp.Animals.- Antisense Properties of Peptide Nucleic Acid.-Triple Stranding Strategies and Progress.