Antiviral Methods and Protocols by Derek KinchingtonAntiviral Methods and Protocols by Derek Kinchington

Antiviral Methods and Protocols

byDerek KinchingtonEditorRaymond F. Schinazi

Paperback | October 8, 2011

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Experienced scientists describe-in an easily-followed format-their state-of-the-art techniques for evaluating antiviral compounds. The assays described include systems for investigating drugs used against herpesviruses, hepatitis viruses, human immunodeficiency viruses, human papillomaviruses, and influenza viruses. These well-tested methods range from cellular assays to some of the most up-to-date molecular approaches for identifying compounds that are active against viral enzymes and the development of viral resistance against drugs currently in use. Timely and comprehensive, Antiviral Methods and Protocols offers today's researchers in academia, clinical departments, and the pharmaceutical industry the powerful, reproducible, and novel methods needed to evaluate compounds effective against both acute and chronic infections.
Title:Antiviral Methods and ProtocolsFormat:PaperbackDimensions:404 pages, 22.9 × 15.2 × 0.02 inPublished:October 8, 2011Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617370738

ISBN - 13:9781617370731

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Table of Contents

Changing Methods for Discovering Antiviral DrugsPhilip S. JonesLaboratory Safety ConsiderationsPaul M. Feorino, John D. Williamson, and Raymond F. SchinaziRoutine Quality Control Testing of Cell Cultures: Detection of MycoplasmaAlison Stacey and Glyn StaceyPart I. Hepatitis VirusHep AD38 Assay: A High-Throughput, Cell-Based Screen for the Evaluation of Compounds Against Hepatitis B VirusRobert W. King and Stephanie K. LadnerHepatitis B Virus Cell Culture Assays for Antiviral ActivityKaren Schmidt and Brent KorbaA Rapid Microtiter Assay for Duck Hepatitis Virus Reverse TranscriptaseMichael J. Otto and Richard A. WhitakerAssays for Measuring Hepadnaviral Supercoiled DNAStephen A. Locarnini and Gilda M. CiviticoAssays for Hepatitis B Virus DNA- and RNA-Dependent DNA Polymerase ActivitiesTimothy Shaw and Stephen A. LocarniniDevelopment of a Hepatitis C Virus RNA Helicase High Throughput AssayAnn D. Kwong and Christine RisanoPart II. HerpesvirusDetermination of Viral Infectivity: HSV, VZV, and CMVDavid R. HarperAntiviral Screening Assays for Human Herpesviruses 6 and 7Jodi B. Black and Philip E. PellettStrategies for Evaluation of Antiviral Agents Against Epstein-Barr Virus in CultureJung-Chung LinMonitoring Drug Resistance for HerpesvirusesGraciela Andrei, Pierre Fiten, Erik De Clercq, Robert Snoeck, and Ghislain OpdenakkerHerpesvirus Protease AssaysPeter Ertl, Linda Russell, and Jane AngierPart III. Human Immunodeficiency VirusTesting Compounds for Antiviral Activity in Cell Cultures Infected with HIVDonna Devine, Naomi Mathews, and Derek KinchingtonEvaluation of Compounds That Prevent Reactivation of HIV-1 in OM-10.1 CellsSalvatore T. ButeraAssessment of Activity of Topical Virucidal AgentsTimothy O'ConnorAssays That Measure Selective Killing of Virus-Infected CellsSharon RandallEvaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV DrugsAnne-Mieke Vandamme, Myriam Witvrouw, Christophe Pannecouque, Jan Balzarini, Kristel Van Laethem, Jean-Claude Schmit, Jan Desmyter, and Erik De ClercqLine Probe Assay for Detecting Mutations in HIV-1 Reverse TranscriptaseLieven Stuyver, Ann Wyseur, Gonda Verpooten, and Rudi RossauRT-PCR for Amplification of Specific Fragments of HIV-1 GenomeMarie-Pierre de Béthune and Kurt HertogsEvaluation of Compounds Against Recombinant HIV Reverse TranscriptaseJan BalzariniUltrasensitive Detection of Reverse Transcriptase Activity by the Amp-RT Assay: Applications to the Measurement of Virus Loads and Phenotypic Drug ResistanceJ. Gerardo García Lerma and Walid HeneineReverse Transcriptase Assay Based on Product Enhancement for Assessing the Drug Susceptibility of RetrovirusesJürg Böni and Jörg SchüpbachIdentifying and Characterizing HIV Protease InhibitorsEric S. FurfineRetroviral Integrase: A Novel Target in Antiviral Drug Development and Basic In Vitro Assays with the Purified EnzymeAbhijit Mazumder, Nouri Neamati, Sanjay Sunder, Joshua Owen, and Yves PommierPart IV. Human Papilloma VirusPapillomavirus DNA ReplicationMaureen C. Ferran and Alison A. McBrideQuantitative Immunodetection of Viral Oncoprotein Levels in Human Papillomavirus-Transformed Human CellsJeffery A. Johnson and J. David GangemiPart V. Influenza VirusesBiochemical Methods for the Characterization of Influenza Viruses with Reduced Sensitivity to 4-Guanidino-Neu5Ac2enRichard C. Bethell, Graham J. Hart, Tony J. Blick, Anjali Sahasrabudhe, and Jennifer L. McKimm-BreschkinVirological Methods for the Generation and Characterization of Influenza Viruses with Reduced Sensitivity to 4-Guanidino-Neu5Ac2enJennifer L. McKimm-Breschkin, Anjali Sahasrabudhe, Tony J. Blick, Amanda J. Jowett, and Richard C. BethellIndex

Editorial Reviews

"...will be of great benefit to all involved with antiviral development..." -Antiviral Research"...Together with some useful general discussions on safety and new approaches to antiviral research this volume offers extremely useful information for both the pharmaceutical industry and the academic researcher."-Microbiology Today"...the editors are to be congratulated for assembling an impressive array of experts in the field as authors for the chapters and the book should remain a valuable reference work for many years, despite the rapidly moving nature of the discipline." - Journal of Antimicrobial Chemotherapy