Apoptosis and Cancer Chemotherapy by John A. HickmanApoptosis and Cancer Chemotherapy by John A. Hickman

Apoptosis and Cancer Chemotherapy

EditorJohn A. Hickman, Caroline Dive

Paperback | November 19, 2010

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This collection of thoughtful and provocative articles focused on the key issues in apoptosis, ranges from the role of apoptosis in defining the response of authentic tumor populations to chemotherapeutic agents to the mechanisms coupling DNA damage to the activation pathway of apoptosis. It reviews the profusion of new signaling, modulating, and effector molecules now implicated in apoptosis and whether other routes to "programmed" cell death may exist. Also addressed are the nature of the molecules that will either constitute targets for future drugs or influence the efficacy of current therapies, as well as mechanistic questions on the control of apoptosis. By focusing on essential questions and critically summarizing the overwhelming tide of recent research results, Apoptosis and Cancer Chemotherapy illuminates not only the potential targets for tumor therapy, but beyond that, potential control points for cancer and such diverse diseases as viral infection, neurodegenerative disorders, and stroke. This collection of cutting-edge reviews by established leaders in the field critically summarizes the recent discoveries concerning apoptosis, cell suicide. The book looks forward to the time when such cell death can be controlled to treat cancer and a host of other diseases as diverse as viral infection, neurodegenerative disorders, and stroke.
Title:Apoptosis and Cancer ChemotherapyFormat:PaperbackDimensions:357 pages, 9.25 × 6.1 × 0.01 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617371653

ISBN - 13:9781617371653

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Table of Contents

Foreword, Andrew H. Wyllie. Does Apoptosis Contribute to Tumor Cell Sensitivity to Anticancer Agents?, J. Martin Brown and Bradly G. Wouters. p53, Apoptosis, and Chemosensitivity, Scott W. Lowe. The Role of p53 in Chemosensitivity, Wafik S. El-Deiry. Function of the p53 Gene Family: A Holistic Perspective, Sandra J. Campbell, Mary O'Neill, and Peter A. Hall. Mismatch Repair Deficiency, Apoptosis, and Drug Resistance, Robert Brown. Involvement of the c-Abl Tyrosine Kinase in Apoptotic Response to Anticancer Agents, Zhi-Min Yuan, Surender Kharbanda, Ralph Weichselbaum, and Donald Kufe. Bcl-2 Family Proteins: Relative Importance as Determinants of Chemoresistance in Cancer, John C. Reed. Bax, A Death Effector Molecule: Its Role in Development and Oncogenesis, Yi-Te Hsu and Richard. Youle. Bax, A Proapoptotic Protein Forming Channels in Mitochondria, Jean-Claude Martinou and Bruno Antonsson. Mechanism of Action of the Proapoptotic Gene Bak, Robin Brown. Killers or Clean-Up Crew: How Central are the Central Mechanisms of Apoptosis?, Douglas R. Green and Helen M. Beere. Role of CD95 (APO-1/Fas) System in Chemotherapy, Klaus-Michael Debatin. Insulin-Like Growth Factor-1 Receptor as a Target for Anticancer Therapy, Renato Baserga and Mariana Resnicoff. Drug Resistance and the Survival Niche: Survival Signals Combine to Suppress Drug-Induced Apoptosis in B-Lymphoma Cells, Sian T. Taylor and Caroline Dive. Chemotherapy, Tumor Microenvironment, and Apoptosis, Constantinos Koumenis, Nicholas Denko, and Amato J. Giaccia. Molecular Regulation and Therapeutic Implications of Cell Death in Prostate Cancer, Timothy J. McDonnell, Elizabeth M. Bruckheimer, Bjorn T. Gjertsen, Tsuyoshi Honda, and Nora M. Navone. Chemotherapy and Apoptosis in the Ovary: CancerTreatment Comes with a Price, Jonathan L. Tilly and Alan L. Johnson. Role of Bcl-2 Family Members in Homeostasis, in Toxicology in Normal Intestine, and for Prognosis of Colonic Carcinomas, D. Mark Pritchard. Apoptosis and Breast Cancer, Nancy E. Davidson, Hillary A. Hahm, and Deborah K. Armstrong. Role of Apoptosis in Human Neuroblastomas, Garrett M. Brodeur and Valerie P. Castle. Response of Testicular Tumors to Chemotherapy: Relative Role of Drug-DNA Interactions and Apoptosis, Christine M. Chresta. Concluding Remarks: Has the Information Explosion on Apoptosis Affected Clinical Practice?, Joseph R. Bertino. Index.

Editorial Reviews

"This book provides a balanced view on the current knowledge on the relation between apoptosis and chemotherapy...The greatest merit of the book is to gather the different opinions about the relevance of apoptosis in chemosensitivity...Another positive aspect of this book is the effort made in having a relatively recent update presentation in most chapters, what is quite a remarkable achievement in a field where new molecules and pathways are continuously being discovered and described. Furthermore, the main concepts are discussed throughout this book in a balanced fashion, combining solid literature with some speculation, sometimes rather provocative as well...a book that pays off, since it provides an informative journey through a complex and interesting field. This book should be recommended not only for medical oncologists interested in molecular and mechanistic discussion about chemosensitivity, but also for basic scientists working in the field of drug-induced apoptosis."-Annals of Oncology"This book of 21 chapters is a clinically relevant assessment of the chemotherapeutic significance of apoptosis in cancer treatment...the chapters are well written, relatively up to date and reasonably well illustrated."-Cell Biology International"This book is of value to many scientists as a current reference to a complicated field. It also provides a balanced view of the field and warns investigators that complexity is the norm and over-simplification is a laboratory phenomenon."-Oncology"...This book is an excellent critical summary of where the field is today...This is an excellent book with up to date references useful to graduate students, clinicians and researchers who, in a few hours reading would gain a broad overview of the current field."-Today's Life Science"This volume represents the most comprehensive work devoted to the subject, and the editors have done an outstanding job of recruiting some of the most prominent researchers in the field....the book is an outstanding resource and should be extremely valuable to all investigators interested in cancer research."-Quarterly Review of Biology