Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification by Myrtle A. DavisApoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification by Myrtle A. Davis

Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification

byMyrtle A. Davis

Paperback | October 8, 2011

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Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.
Title:Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and QuantificationFormat:PaperbackDimensions:156 pages, 22.9 × 15.2 × 0.02 inPublished:October 8, 2011Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617372390

ISBN - 13:9781617372391

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Table of Contents

IntroductionMyrtle A. DavisFlow Cytometric and Fluorometric Methods of Quantifying and Characterizing Apoptotic Cell DeathMartin Poot, Robert H. Pierce, and Terrance J. KavanaghAnalysis of Apoptosis by Laser Scanning CytometryZbigniew Darzynkiewicz, Elzbieta Bedner, and Piotr SmolewskiSpecific Methods for Detection and Quantification of Apoptosis in Tissue SectionsMatthew A. Wallig, Curtis M. Chan, and Nancy A. GillettDNA Microarrays: An Overview of Technologies and ApplicationsHelmut ZarblMicroarray Analysis of ApoptosisRichard W. E. Clarkson, Catherine A. Boucher, and Christine J. WatsonELISAs for Quantification of Bcl-2 Family Activities and Active CaspasesCalvin F. Roff, Amy M. Walz, Lisa B. Niehoff, David J. Sdano, Antoinette M. Bennaars, Jeffrey A. Cooper, Becky L. Senft, Anatoli A. Sorkin, Steven P. Stoesz, and Paul A. SaundersIndex

Editorial Reviews

"The book emphasizes techniques that can be used to quantify apoptosis, such as cell morphology, flow cytometry, laser-scanning cytometry, ELISA, and DNA microarray. The flow cytometry and ELISA sections are the best, as they are applicable to a wide range of laboratories because of their ease of use do not require any extraordinary facilities. . .The book is well written and instructive, and the techniques described can be applied easily to topics in pharmacology and toxicology as well as in general apoptosis research. A strong point is that the authors emphasize the need to combine morphological assessment of the cell with other apoptotic parameters in order to fully characterize a cell as apoptotic."-Doody's Health Science Book Review Journal