Apoptosis: The molecular biology of programmed cell death

Paperback | March 1, 2002

EditorMichael Jacobson, Nicola McCarthy

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Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity toapoptotic triggers can cause cells to be lost inappropriately from tissues, as appears to occur in neurodegenerative diseases. This book examines the molecular pathways regulating apoptosis, progressing from the nematode worm through Drosphila to the more complex pathways evident in mammalian cells. Differences in the cell death pathway within specific tissues are addressed, as are the different genes that may act toregulate progressive steps.

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Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity toapoptotic triggers can cause cells to be lost ...

Michael Jacobson is at Millennium Pharmaceuticals Inc., Cambridge, MA, USA. Nicola McCarthy is at Division of Cardiovascular Medicine, Addenbrookes Hospital, Cambridge, UK.

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Format:PaperbackDimensions:346 pages, 9.69 × 7.44 × 0.83 inPublished:March 1, 2002Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199638497

ISBN - 13:9780199638499

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Table of Contents

1. Nicola McCarthy: Why be interested in death?2. Ding Xue, Yi-Chun Wu, Manisha Shah: Programmed cell death in C.elegans: the genetic framework3. Andreas Bergmann, Hermann Steller: Genetic and molecular analysis of programmed cell death in Drosophila4. Natalie Roy, Michael Cardone: The caspases: from here to eternity5. Yoshihide Tsujimoto: Regulation of apoptosis by the Bcl-2 family of proteins6. Naoufal Zamzami, Santos Susin, Guido Kroemer: Mitochondria in apoptosis: Pandora's Box7. Paul Clarke: Apoptosis: lessons from free cell systems8. Nicola McCarthy, Martin Bennett: Death signalling by the CD95/TNFR family of death domain containing receptors9. Thomas Franke: Survival signalling by phosphorylation: PI3K/Akt sets the stage10. David Vaux: Viruses and apoptosis11. Michael Jacobson, Louise Bergeron: Cell death in the nervous system

Editorial Reviews

"ÝW¨ell-written ... readable and thought provoking ... The editors each contribute excellent essays."--The Quarterly Review of Biology