Assessing Quality of Life in Clinical Trials: Methods and practice

Hardcover | March 22, 2005

EditorPeter Fayers, Ron Hays

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Quality of Life Assessment has progressed considerably since the publication of the first highly acclaimed edition of this book in 1998. Quality of life has now become an indispensable outcome measure in many randomised clinical trials and other studies. Thus, it is timely to provide not justan update, but a completely new edition that reviews the current state of art and also discusses topical issues including areas where active research is in progress. The first section discusses the development and evaluation of generic and disease-targeted questionnaires. Having decided the items to be included the thrust of the next section covers how to convert these into usable forms. Section 3 addressing analysis and the methods of analysing studies withmissing data is followed by chapters on interpretation of results and exploring the role of single-item questions. The final section of the book looks beyond the individual clinical trial and how we can use clinical trial and other data to make macro-decisions. A strong international team of experts cover a wide range of topics, emphasizing new and innovative approaches that are of practical and clinical importance, reviewing the current state of the art and illustrating the benefits and potential of health related quality of life assessment in clinicaltrials.

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From the Publisher

Quality of Life Assessment has progressed considerably since the publication of the first highly acclaimed edition of this book in 1998. Quality of life has now become an indispensable outcome measure in many randomised clinical trials and other studies. Thus, it is timely to provide not justan update, but a completely new edition tha...

Peter Fayers is at Department of Public Health, Aberdeen Medical School, Aberdeen, UK. Ron Hays is at UCLA School of Medicine, Division of GIM and Health Services Research, UCLA, Los Angeles, USA.

other books by Peter Fayers

Format:HardcoverDimensions:482 pages, 9.45 × 6.61 × 1.24 inPublished:March 22, 2005Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198527691

ISBN - 13:9780198527695

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Table of Contents

Preface1. Developing and evaluating questionnaires1.1. Ron Hays: Generic versus disease-targeted instruments1.2. Elaine McColl: Developing questionnaires1.3. Ron Hays and Dennis Revicki: Reliability and validity, including responsiveness1.4. Ron Hays and Peter Fayers: Evaluating multi-item scales1.5. Bryce Reeve and Peter Fayers: Rasch models and IRT2. Adapting and using questionnaires2.1. Patrick Marquis: Translating and evaluating questionnaires - cultural issues2.2. Jakob Bjorner and John Ware: CAT and item banking2.3. David Cella: Developing a questionnaire using IRT - a case study of fatigue2.4. Elaine McColl and Peter Fayers: Proxy assessments and context effects3. Analysis3.1. Diane Fairclough: Analysing longitudinal studies of QOL3.2. Dennis Revicki and Diane Fairclough: Preventing missing data3.3. Diane Fairclough: Analysing studies with missing data3.4. Mogens Groenvold and Morten Petersen: Differential item functioning (DIF) for analysing cultural differences3.5. Dennis Revicki: Reporting analyses from clinical trials4. Interpreting QoL in individuals and groups4.1. Ciaran O'Boyle, Stefan Hofer and Lena Ring: Individualised QoL4.2. David Osoba and Madeleine King: Meaningful differences4.3. David Osoba: Health-related QoL outcomes in clinical trials4.4. Carolyn Schwartz, Mirjam Sprangers and Peter Fayers: Response shift4.5. Galina Velikova and Penny Wright: Individual patient monitoring5. Measures for clinical trials5.1. Jakob Bjorner, Peter Fayers and Ellen Idler: Self-rated health5.2. Stephen Coons and Jim Shaw: Generic adult health status measures5.3. Jeanne Landgraf: Measurement of HRQL in child/adolescent clinical trials5.4. Barbara Vickrey: Developing disease-targeted measures for neurolgic conditions6. Beyond clinical trials6.1. Paul Kind: Values and valuation6.2. David Feeny: Preference-based measures6.3. Mandy Ryan and Karen Gerard: Discrete choice experiments6.4. Peter Fayers and Neil Scott: Combining clinical trials - meta analysis

Editorial Reviews

`A useful resource for those undertaking or appraising trials. I know of no other books that deal with the subject in such detail, and it contains some gems. In future, when I am taking part in the design or conduct of clinical trials, I will repeatedly return to this book for advice.'Journal of the Royal Society of Medicine