Astrocytes And Epilepsy by Jacqueline A. HubbardAstrocytes And Epilepsy by Jacqueline A. Hubbard

Astrocytes And Epilepsy

byJacqueline A. Hubbard, Devin K. Binder

Hardcover | July 25, 2016

Pricing and Purchase Info


Earn 863 plum® points

Prices and offers may vary in store

Out of stock online

Not available in stores


Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal ofAstrocytes and Epilepsyis to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy.

Astrocytes and Epilepsyincludes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field.Astrocytes and Epilepsyis written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy.

  • Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume
  • Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions
  • Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
Jacqueline A. Hubbard received her B.S. in biochemistry from the University of Vermont. Her M.S. and Ph.D. were both completed at the University of California, Riverside. She has been working in Devin Binder's laboratory since 2011 and her research focuses on characterizing astrocytic changes in epilepsy. Specifically, she uses in vivo...
Title:Astrocytes And EpilepsyFormat:HardcoverDimensions:394 pages, 9.41 × 7.24 × 0.98 inPublished:July 25, 2016Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128024011

ISBN - 13:9780128024010

Look for similar items by category:


Table of Contents

1. History of astrocytes

2. Astrocytes in the mammalian brain

3. Gliotransmitters

4. Types of epilepsy

5. Neuropathology of human epilepsy

6. Astrocyte calcium signaling

7. Potassium channels

8. Water channels

9. Glutamate metabolism

10. Adenosine metabolism

11. Gap junctions

12. Blood-brain barrier disruption

13. Inflammation

14. Therapeutic targets and future directions