Atherosclerosis: The Role of Gene Expression, Cell Interactions, and Oxidation

Hardcover | November 1, 2000

EditorRoger Dean, David Kelly

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This book provides a critical review of the oxidative theory of atherosclerosis as well as highlighting new trends in research from basic to clinical, academic to commercial. The contributions of diabetes, vascular dysfunction, blood coagulation, plaque rupture, oxidative stress, lymphocytes,macrophages, growth factors, cytokines, and oxysterols to atherogenesis are all discussed, as are the roles of smooth muscle and endothelial cells. As well as a summary of the current methods of diagnosis and the future prospect of using biochemical markers from plasma is also discussed. There is acritical look at gene therapy and other future therapeutic strategies based on the molecular and cellular causes of atherosclerosis. Each chapter is written by two or more authors from different laboratories to ensure a balanced approach. It will be invaluable to all biomedical researchers with aspecialist or passing interest in atherosclerosis research.

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This book provides a critical review of the oxidative theory of atherosclerosis as well as highlighting new trends in research from basic to clinical, academic to commercial. The contributions of diabetes, vascular dysfunction, blood coagulation, plaque rupture, oxidative stress, lymphocytes,macrophages, growth factors, cytokines, and ...

Roger Dean is at The Heart Research Institute, Sydney. David Kelly is at The Heart Research Institute, Sydney.

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Format:HardcoverPublished:November 1, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198506376

ISBN - 13:9780198506379

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Table of Contents

The morphology and natural history of atherosclerosis; Diabetes and atherosclerosis; Antioxidant intervention studies in small animals; Antioxidant intervention studies in humans; Vascular dysfunction and its contribution to atherosclerosis; Gene therapy for vascular diseases: closer to deliveringthe goods; The endothelial cell in atherosclerosis; Oxidative stress and platelet formation in atherosclerosis; Macrophage lipid metabolism and atherosclerosis; Smooth muscle cells and the connective tissue matrix of the initima; Lymphocytes in atherogenesis; Growth factors and cytokines inatherogenesis; Lipoprotein influx and efflux in the atherosclerotic intima; Inhibition of the cytokine-induced expression of endothelial cell adhesion molecules by high density lipoproteins; Protein oxidation in atherogenesis; Anti-oxidants and co-antioxidation in lipoproteins and the intima;Oxysterols in atherogenesis;Intracellular effects of cell surface-localized initiation of blood coagulation; Plaque rupture and its consequences; Diagnosis and thera

Editorial Reviews

" ... this book will be of greatest value to investigators involved in cardiovasular research." Nature Cell Biology