ATP and the Heart by Joanne S. IngwallATP and the Heart by Joanne S. Ingwall

ATP and the Heart

byJoanne S. Ingwall

Paperback | October 30, 2012

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ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events in the intact beating heart and using new animal models in which cardiac proteins are either over expressed, deleted or harbor specific mutations.

This book provides a summary of the basic understanding and includes illustrations of whyATP and the Heartis important to both the clinician and scientist.

Title:ATP and the HeartFormat:PaperbackDimensions:244 pagesPublished:October 30, 2012Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1461353912

ISBN - 13:9781461353911

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Table of Contents

List of Topics. Prologue. Part I: ATP: The Molecule. 1. ATP and the heart: An overview. 2. The basics. 3. The chemistry of the ATPase reaction. 4. Ways to measure ATP and related metabolites. Part II: ATP: Degradation Pathway and De Novo Synthesis. 5. Degradation and synthesis of ATP. Part III: ATP Utilizing Pathways. 6. The work of contraction: Myosin ATPase. 7. The work of ion movements. 8. The work of macromolecular synthesis and degradation. Part IV: ATP Synthesizing Pathways. 9. ATP synthesis pathways: glycolysis. 10. ATP synthesis pathways: oxidative phosphorylation. 11. ATP synthesis pathways: phosphotransferase reactions. Part V: ATP and the Heart. 12. Integration of ATP synthesis and ATP utilization pathways. Index.