Autism: Current Theories and Evidence by Andrew W. ZimmermanAutism: Current Theories and Evidence by Andrew W. Zimmerman

Autism: Current Theories and Evidence

EditorAndrew W. Zimmerman

Paperback | November 19, 2010

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Creative thinking and collaborative scientific research have advanced our understanding of autism, and we are now beginning to synthesize the data into evidence and theories. Autism: Current Theories and Evidence presents current theories about autism and the evidence that supports them. The goal is to show how the scientific method is revealing the biological bases of this spectrum of disorders, thereby leading the way to their treatment and prevention using evidence-based medicine. This book has 20 chapters divided into 6 sections: Molecular and Clinical Genetics; Neurotransmitters and Cell Signaling; Endocrinology, Growth and Metabolism; Immunology, Maternal-Fetal Effects and Neuroinflammation; Neuroanatomy, Imaging and Neural networks; and Environmental Mechanisms and Models. The subjects cover a wide range of current scientific work in the field of autism, with strong and growing evidence to support them, and demonstrate both the breadth and depth of current autism research. The reader is encouraged to consider how theories and the scientific method, in the hands of these and other dedicated researchers, are leading to greater knowledge and continued progress in autism research.
Title:Autism: Current Theories and EvidenceFormat:PaperbackDimensions:493 pages, 9.25 × 6.1 × 0.04 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617379018

ISBN - 13:9781617379017

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Table of Contents

Table of Contents Preface Moving Beyond Hypotheses: A Call for Theories and EvidenceAndrew W. Zimmerman I. Molecular and Clinical GeneticsChapter 1ENGRAILED2 and Cerebellar Development in the Pathogenesis of Autism Spectrum DisordersIan T. Rossman and Emanuel DiCicco-Bloom Chapter 2Teratogenic Alleles in Autism and Other Neurodevelopmental DisordersWilliam G. Johnson, Madhura Sreenath, Steven Buyske and Edward S. Stenroos Chapter 3Cholesterol Deficit in Autism: Insights from Smith-Lemli-Opitz Syndrome Alka Aneja and Elaine Tierney Chapter 4Autism in Genetic Intellectual Disability: Insight into the Bases and Features of Idiopathic AutismWalter E. Kaufmann, George T. Capone, Megan Clarke and Dejan B. Budimirovic II. Neurotransmitters and Cell SignalingChapter 5Serotonin Dysfunction in AutismMary E. Blue, Michael V. Johnston, Carolyn Boylan Moloney and Christine F. Hohmann Chapter 6Excitotoxicity in Autism: The Role of Glutamate in Pathogenesis and TreatmentMartin Evers and Eric Hollander Chapter 7Prenatal Beta 2 Adrenergic Receptor Signaling and Autism: Dysmaturation and Retained Fetal FunctionSusan L. Connors IV. Endocrinology, Growth and MetabolismChapter 8A role for fetal testosterone in human sex differences: Implications for Understanding autismBonnie Auyeung and Simon Baron-Cohen Chapter 9Interaction between Genetic Vulnerability and Neurosteroids in Purkinje cells as a Possible Neurobiological Mechanism in Autism Spectrum DisordersFlavio Keller, Roger Panteri, Filippo Biamonte Chapter 10Insulin-like growth factors: Neurobiological regulators of brain growth in autism?Raili RiikonenChapter 11Oxidative Stress and the Metabolic Pathology of AutismS. Jill James V. Immunology, Maternal-Fetal Interaction and NeuroinflammationChapter 12The Immune System in Autism: is there a Connection?Luke Heuer, Paul Ashwood and Judy Van de WaterChapter 13Maternal Immune Activation, Cytokines and AutismPaul H. Patterson, Wensi Xu, Stephen E. P. Smith and Benjamin E. Deverman Chapter 14Maternal Antibodies and the Placental-Fetal IgG Transfer Theory Christina M. Morris, Mikhail Pletnikov, Andrew W. Zimmerman, and Harvey S. Singer Chapter 15Can Neuroinflammation Influence the Development of Autism Spectrum Disorders?Carlos A. Pardo-Villamizar VI. Neuroanatomy and Neural networksChapter 16The Significance of Minicolumnar Size Variability in Autism: A Perspective from Comparative AnatomyManuel F. Casanova Chapter 17Imaging evidence for pathological brain development in Autism Spectrum DisordersStephen R Dager, Seth D Friedman, Helen Petropoulos and Dennis WW Shaw Chapter 18Information Processing, Neural Connectivity, and Neuronal Organization Nancy J. Minshew, Diane L. Williams, and Kathryn McFadden VII. Environmental Mechanisms and ModelsChapter 19Evidence for Environmental Susceptibility in Autism: What We Need to Know About Gene x Environment InteractionsIsaac N. Pessah and Pamela J. Lein  Chapter 20An Expanding Spectrum of Autism Models: From Fixed Developmental Defects to Reversible Functional Impairments Martha R. Herbert and Matthew P. Anderson

Editorial Reviews

From the reviews:"Autism: Current Theories and Evidence, edited by Andrew Zimmerman, serves as an atlas or geophysical study of the archipelago of autism. . this book is a valuable contribution to the effort to map autism, and it is a demonstration of the type of cooperation that is needed across scientific disciplines if progress is to be made in this effort." (Jeffrey A. Munson, The New England Journal of Medicine, Vol. 360 (23), June, 2009)"All chapters are uniformely arranged with initial abstract, many informative subheadings, tables and impressive figures. All of them are clearly written . . the present book provides an impressive, evidence-based review of pathogenesis, clinical features, genetics, biological bases, pathogenetic factors, current or future treatments of ASDs. It is therefore recommended to all clinicians and neuroscientist who are interested and engaged in the complex field of ASDs." (K. A. Jellinger, European Journal of Neurology, Vol. 16, 2009)"The book has 20 chapters divided into 6 parts. . Mainly, but not only, for neurobiologists, psychologists and psychiatrists. Recommended." (Pediatric Endocrinology Reviews, Vol. 8 (2), December, 2010)