Autoimmunity by Andrzej GórskiAutoimmunity by Andrzej Górski


byAndrzej GórskiEditorHubert Krotkiewski, Michal Zimecki

Paperback | September 25, 2012

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The immune system has evolved mechanisms enabli ng it to discriminate between self and non-self constituents. A normally functioning organism is naturally unresponsive to self antigens originating from clonal deletion, aner­ gy, or an active suppression of self-reactive T cells. The wide spectrum of autoimmune responses may be divided into systemic and organ-specific dis­ eases and encompasses the actions of autoantibodies, autoantigeu-autoanti­ body complexes, and sensitized T lymphocytes. The aim of this book is to review the current understandin g, concepts and hypotheses regarding the pathogenesis and therapeutic approaches in autoim­ mune disorders. The first six articles are generally concerned with the mech­ anisms operating in autoimmune phenomena, whereas the subsequent reviews discuss particular phenomena in representative autoimmune dis­ eases. The introductory article underlines the significance of the interactions between antigen-specific T cells and other elements ot the immune system and proposes that not suppression, but rather activation of the immune sys­ tem, leading to a redirection of the immune response, would be therapeuti­ cally beneficial. The next articles present the importance of costim ulatory signals in determining various types of immune responses, including autoim­ munity, and the role of regulatory T cells. Further, an interesting phenome­ non of epitope spreading as a mechanism for the progression of autoimmune diseases is presented.
Title:AutoimmunityFormat:PaperbackDimensions:207 pagesPublished:September 25, 2012Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9401038775

ISBN - 13:9789401038775

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Table of Contents

The Paradigms of Causality and Treatment for Autoimmune Disease; I.R. Cohen. Uncovering the Differences between T Cell Tolerance and Immunity; A.T. Vella. The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: Generation, Specificity and Mode of Action; B. Seddon. Epitope Spreading: a Mechanism for Progression of Autoimmune Disease; V.K. Tuohy, R.P. Kinkel. A Role for NF-kappaB and the Proteasome in Autoimmunity; T. Hayashi, D. Faustman. Complement Regulatory Proteins and Autoimmunity; M. Kawano. Pathogenic Immunity in Theiler's Virus-Induced Demyelinating Disease: a Viral Model for Multiple Sclerosis; B.S. Kim, et al. Evidence that Fas and FasL Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis; B.N. Dittel. The Role of Cytokines in Experimental Autoimmune Encephalomyelitis; E. Bettelli, L.B. Nicholson. Involvement of Apoptotic Protease Cascade for Tissue Destruction in Sjögren's Syndrome; Y. Hayashi. Is Lack of Peripheral Tolerance Induction a Cause for Diabetes in the Non-Obese Diabetic Mouse? T. Lund, J. Strid. Neuro-Endocrine-Immune Axis in Human Rheumatoid Arthritis; T. Sakane, N. Suzuki. The Role of T Cells in Rheumatoid Arthritis; C.M. Weyand, et al. Index.