Automation: Genomic and Functional Analyses

Paperback | December 28, 1998

byAlister G. CraigEditorJörg D. Hoheisel

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Automation is the major future trend for many areas in microbiology, molecular biology, and biochemistry, among other disciplines. It is an enormously exciting area, where techniques and assays that were once repetitive, tedious, and time consuming can be performed robotically, liberating the time of researchers and hospital laboratory workers for more interesting work. Many techniques have now been automated and often miniaturized, including PCR analysis, DNA/RNA preparation, diagnostic test e.g., Pap tests , compound screening, and of course, sequencing. Some major advances, notably in Professor Leroy Hood's group, have resulted in the ability to perform thousands of assays simultaneously on a normal microscope slide.Automation , edited by two of the leading experts in the field, presents the very latest experimental techniques explained in detail. This book has succeeded in bringing together researchers at the forefront of clone library construction, genome analysis, sequencing, computational data evaluation and functional analysis, to provide insight into this "new age" of research based on genomic and chemical screening. Key Features * Describes automated procedures used in microbiology and molecular biology* Includes developments in robotics and vision systems* Features automation in library picking, presentation and analysis* Discusses paralogous duplications in microbial genomes* Covers deciphering genomes through automated large-scale sequencing* Describes and stresses the need for functional analyses* Internationally acclaimed contributors, including Professor Leroy Hood

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From Our Editors

The entire world is moving toward automation, so why should it be any different in such disciplines as biochemistry and microbiology? In fact, the truth is that automation is making life much easier for scientists and laboratory workers by allowing them more time to concentrate on the more challenging aspects of their research. In Auto...

From the Publisher

Automation is the major future trend for many areas in microbiology, molecular biology, and biochemistry, among other disciplines. It is an enormously exciting area, where techniques and assays that were once repetitive, tedious, and time consuming can be performed robotically, liberating the time of researchers and hospital laboratory...

From the Jacket

Established for almost 30 years,Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalised, with a new format and expanded scope,Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your re...

Jorg D. Hoheisel received his Ph.D. in 1988 from the University of Konstanz, Germany, where he studied DNA structures. He was at the ICRF in London, UK from 1988 to 1993, working on genome analysis. Since 1993, he has been Head at the DKFZ (Deutsches Krebsforschungzentrum) in Heidelberg, Germany.
Format:PaperbackDimensions:270 pages, 9.5 × 6.5 × 0.68 inPublished:December 28, 1998Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0121948609

ISBN - 13:9780121948603

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Table of Contents

L. Hood, Foreword.
U. Pettersson, Introduction.
A. Fife and D.W.M. Crook, Automation in Clinical Microbiology.
A.J.McCollum, Vision Systems for Automated Colony and Plaque Picking.
D.R. Bancroft, E. Maier and H. Lehrach, Library Picking, Presentation and Analysis.
G. Kauer and H. Blöcker, The PREPSEQ Robot: An Integrated Environment for Fully Automated and Unattended Plasmid Preparations and Sequencing Reactions.
A.N. Hale, Building Realistic Automated Production Lines for Genetic Analysis.
A.N. Hale, Examples of Automated Genetic Analysis Developments.
L. Rowen, S. Lasky and L. Hood, Deciphering Genomes Through Automated Large-scale Sequencing.
N.C. Hauser, M. Scheideler, S. Matysiak, M. Vingron and J.D. Hoheisel, DNA Arrays for Transcriptional Profiling.
K.-J. Reiger, G. Orlowska, A. Kaniak, J.-Y. Coppee, G. Alijinovic and P.P. Slonimski, Large-scale Phenotypic Analysis in Microtitre Plates of Mutants with Deleted Open Reading Frames From Yeast Chromosome III: Key-step Between Genomic Sequencing And Protein Function.
J.J. Codani, J.P. Comet, J.C. Aude, E. Glémet, A. Wozniak, J.L. Risler, A. Hénaut and P.P. Slonimski, Automatic Analysis of Large-scale Pairwise Alignments of Protein Sequences.
M.Y. Galperin and D. Frishman, Towards Automated Prediction of Protein Function from Microbial Genomic Sequences.
Index.

From Our Editors

The entire world is moving toward automation, so why should it be any different in such disciplines as biochemistry and microbiology? In fact, the truth is that automation is making life much easier for scientists and laboratory workers by allowing them more time to concentrate on the more challenging aspects of their research. In Automation, Alister Craig and Jörg D. Hoheisel discuss the role of automated techniques in performing such tasks as sequencing, DNA/RNA preparation and PCR analysis. Inside you`ll learn about specific automated mechanisms and read research findings and commentary by Lee Hood.  

Editorial Reviews

"A wide breadth of assays are presented and the focus varies from methodological to instrumentation but the underlying automation theme of the book appears in every chapter ...It is refreshing to finally see a solution-oriented publication that describes in detail how to actually achieve automation in the laboratory."
- TIG