Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, And Aging: Volume 7- Role…

Hardcover | February 18, 2015

byM. A. HayatEditorM. A. Hayat

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Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 7 provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; and the role of autophagy in apoptosis. Attention is given to autophagy in the cardiovascular system, with particular insights into the role of autophagy in atherosclerosis and the distinctive behavior of autophagy in the sinoatrial node. Cutting-edge findings in the relationships between autophagy and lifestyle are explored with the regulation of macroautophagy in response to exercise, as well as the promotion of carcinogenesis via autophagy in response to cigarette smoking. Volume 7 highlights the importance of understanding the role of autophagy in context, as the complexity of autophagic function becomes increasingly clear. Autophagy may be differentially regulated, and may perform distinctive cell-specific functions even within a single tissue. The overall significance of autophagy thus cannot be oversimplified, and must be explored with granular detail of the specific role, function, and area of impact. This book is an asset to newcomers as a concise overview of the complex significance of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation. Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism s underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes. Brings together a wide swathe of experts oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss recent developments in this rapidly-advancing field Discusses the formation of phagophores / autophagosomes, focusing on imaging tools, three-dimensional morphology, and the role of the endoplasmic reticulum Covers role of autophagy in monocyte-macrophage differentiation; cell death in cancer; and apoptosis in odontogenesis Organized for readers into easy-to-access sections: autophagosome biogenesis and regulation; autophagy in protein quality control; autophagy and apoptosis; autophagy in the cardiovascular system; and lifestyle and autophagy

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From the Publisher

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially...

From the Jacket

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially...

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

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Format:HardcoverDimensions:316 pages, 9.41 × 7.24 × 0.98 inPublished:February 18, 2015Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128010436

ISBN - 13:9780128010433

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Extra Content

Table of Contents

Chapter 1. Introduction
I. AUTOPHAGOSOME BIOGENESIS AND REGULATION
Chapter 2. Role of endoplasmic reticulum in the formation of phagophores / autophagosomes: three-dimensional morphology
Joanna Biazik, Helena Vihinen, Eija Jokitalo, Eeva-Liisa Eskelinen
Chapter 3. The nucleus-vacuole junction in saccharomyces cerevisiae
Angela Cadou and Andreas Mayer
Chapter 4. Human Wipis as phosphoinositide effectors at the nascent autophagosome: a robust tool to assess macroautophagy by quantitative imaging
Zsuzanna Takacs and Tassula Proikas-Cezanne
Chapter 5. Induction of autophagy: role of endoplasmic reticulum stress and unfolded protein response
Behzad Yeganeh, Richard Jäger, Adrienne M. Gorman, Afshin Samali and Saeid Ghavami
Chapter 6. Atg16L1 protein regulates hormone secretion independent of autophagy
Koutaro Ishibashi and Mitsunori Fukuda
II. AUTOPHAGY IN PROTEIN QUALITY CONTROL
Chapter 7. Macroautophagy of aggregation-prone proteins in neurodegenerative disease
Leora M. Fox and Ai Yamamoto
Chapter 8. Lithium ameliorates motor disturbance by enhancing autophagy in tauopathy model mice
Yumiko Motoi, Kohei Shimada, and Shin-ei Matsumoto
Chapter 9. Beta-asarone reduces autophagy in a dose-dependent manner and interferes with Beclin 1 function
Yong-Qi Fang and Zhong-Feng Xue
III. AUTOPHAGY AND APOPTOSIS
Chapter 10. Apoptosis and autophagy: The yin-yang of homeostasis in cell death in cancer
Chien-An A. Hu, Kirsten White, Salina Torres, Mohammed-Ali Ishak, Laurel Sillerud, Yubin Miao, Zhihe Liu, Zhenglong Wu, Larry Sklar, and Marianne Berwick
Chapter 11. Role of autophagy and apoptosis in odontogenesis
Lu Zhang and Zhi Chen
Chapter 12. Autophagy is required during monocyte-macrophage differentiation
Yan Zhang, Swati Choksi and Zhenggang Liu
IV. AUTOPHAGY IN THE CARDIOVASCULAR SYSTEM
Chapter 13. Degradation of HSPGS enhances LOX1-mediated autophagy
Shijie Liu, Zufeng Ding, Xianwei Wang, Jawahar L Mehta
Chapter 14. The presence of LC3 and LAMP1 is greater in normal sino-atrial nodal cells than that in ordinary cardiomyocytes, indicating a constitutive event
Mariko Omatsu-Kanbe and Hiroshi Matsuura
V. LIFESTYLE AND AUTOPHAGY
Chapter 15. Regulations of (Macro)-Autophagy in response to exercise
Cécile Jamart and Marc Francaux
Chapter 16. Cigarette smoke promotes cancer via autophagy
Ahmed F. Salem, Federica Stogia, and Michael P. Lisanti

Editorial Reviews

"Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections."--Anticancer Research, February 2015