Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, And Aging: Volume 9: Human…

Hardcover | April 27, 2016

byM. A. Hayat

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 9: Human Diseases and Autophagosome offers a valuable guide to both cellular processes while helping researchers explore their potentially important connections. Volume 9 emphasizes the role of autophagy in diseases, such as leukemia, antifungal and antibacterial immunity, and transplantation. This volume also explains, in detail, the molecular mechanism s underlying the formation of autophagosomes, including the progression of omegasomes to autophagosomes. This information is important because one of the major functions of autophagy is to degrade and eliminate excessive, old, and harmful materials from the cell. Autophagosomes receive these materials cellular cargo and transport them to lysosomes for degradation. Lysosomes contain the digestive enzymes hydrolases that breakdown proteins, lipids, carbohydrates, etc. self-digestion . To further explain this phenomenon, the role of the endoplasmic reticulum ER in the formation of autophagosomes is discussed. ULK1 and Beclin 1 proteins are also important in the initial formation of autophagosomes, and are also discussed. Because much of the early research in this area was carried out using yeast cells, the role of Golgi complex in the autophagosome formation in these cells is explained. This volume also includes an explanation of the role of the autophagy-related gene ATG5 in cancer e.g., gastrointestinal cancer . Paradoxically, autophagy is a double-edged sword because it eliminates some pathogens, whereas it can be used by some intracellular pathogens to multiply and cause infection. This book is an asset to newcomers, providing a concise overview of the role of autophagy in necrosis and inflammation, while also serving as an excellent reference for more experienced scientists and clinicians. Presents the most advanced information regarding the role of the autophagic system in life and death emphasizes autophagy in diseases, such as leukemia Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Edited work with chapters authored by leaders in the field from around the globe the broadest, most expert coverage available

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 9: Human Diseases and Autophagosome offers a valuable guide to both cellular processes while helping researchers explore their potentially important connections. Volume 9 emphasizes the role of autophagy in diseases, such as leukemia, antifungal ...

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

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Format:HardcoverDimensions:430 pages, 9.41 × 7.24 × 0.98 inPublished:April 27, 2016Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128029366

ISBN - 13:9780128029367

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Table of Contents

1. Molecular Mechanisms of Selective Autophagy
2. Atg9 is required for the initiation and Progression of Autophagy: Role of Autophagosome Precursor
3. UVRAG at the Crossroad of Autophagy and Genomic Stability
4. The End or Beginning of Autophagic Cell Death
5. Atg18 is located in Omegasome-Anchored Phagophores and Regulates LC3 lipidation
6. Atg2 proteins are Essential for Autophagosome Formation and Regulation of Lipid Droplets
7. Progression of Omegasomes to Autophagosomes: Molecular Mechanism
8. Role of ULK1 and Beclin 1-PI3KC3 in the Autophagosome Formation
9. Role of Endoplasmic Reticulum in the Formation of Autophagosome
10. Role of Golgi complex in the yeast Autophagosome Formation
11. Recognition of Phosphatidylinositol 3-phosphate by PROPPINs
12. Maintenance of Oxidative Metabolism and Tumorigenesis: Role of RAS-Activated Autophagy
13. Persistent Mitochondrial DNA damage is removed by autophagy
14. Autophagy Promotes T-Cell Survival through Degradation of Proteins of the Cell Death Machinery
15. Cellular/ Immune Response to Stresses: Role of Autophagy
16. Autophagy Attenuates the Adoptive Immune Response by Destabilizing the Immunologic Synapse
17. T-Cell Survival and Proliferation: Role of Autophagy gene ATG5
18. Recessive Mutations in EPG5 cause Vici Syndrome: Role of Defective Autophagy
19. Gastrointestinal Cancer: Role of the Autophagy-Related ATG5 Gene
20. Suppression of Basal Autophagy in Neural Cells causes Neurodegenerative Disease
21. Loss of Autophagy in the Central Nervous System Causes Neurodegeneration