B Cell Receptor Signaling by Tomohiro KurosakiB Cell Receptor Signaling by Tomohiro Kurosaki

B Cell Receptor Signaling

byTomohiro KurosakiEditorJürgen Wienands

Paperback | March 30, 2018

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This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton's Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

Tomohiro Kurosaki, MD, PhD, is a professor at WPI Immunology Frontier Research Center at Osaka University, Japan Jürgen Wienands, PhD, is a professor of Cellular and Molecular Immunology at the University of Göttingen, Germany
Title:B Cell Receptor SignalingFormat:PaperbackDimensions:231 pagesPublished:March 30, 2018Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319798995

ISBN - 13:9783319798998


Table of Contents

Assembly and function of the precursor B-cell receptor.- Receptor Dissociation and B cell activation.- Molecular mechanisms of B cell antigen gathering and endocytosis.- BTK signaling in B cell differentiation and autoimmunity.- The memory function of the B cell antigen receptor.- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL).- Role of Calcium Signaling in B Cell Activation and Biolog.- Roles of the NF-kappaB pathway in B-lymphocyte biology.- MAP kinase cascades in antigen receptor signaling and physiology.