Bacterial Activation of Type I Interferons by Dane ParkerBacterial Activation of Type I Interferons by Dane Parker

Bacterial Activation of Type I Interferons

byDane Parker

Hardcover | October 15, 2014

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The type I interferon (IFN) signaling pathway is well recognized as a pathway activated by viral infections. It is activated by a variety of microbial pattern recognition receptors including the Toll-like receptors, NOD-like receptors and several cytosolic receptors. Activation of the type I IFN pathway leads to the production of both antiviral factors and products that influence immune cell function. More recently it has been shown that bacteria are also capable of activating this pathway.

Bacterial Activation of Type I Interferons reviews both the current understanding of how different bacterial species are able to activate this pathway as well as the influence type I IFNs have on the outcome to infection. Several different bacterial species are covered, spanning Gram positive and Gram negative, intracellular, extracellular, and different host infection sites. An introduction to the pathogenesis of each organism is provided, and the signaling molecules involved in the activation of the type I IFN pathway and the role it plays in animal infection models are also covered.

Title:Bacterial Activation of Type I InterferonsFormat:HardcoverDimensions:129 pagesPublished:October 15, 2014Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319094971

ISBN - 13:9783319094977


Table of Contents

Production and action of type I interferons in host defense.- Induction and consequences of the type I IFN response toListeria monocytogenes.-Innate immune and type I IFN responses duringLegionella pneumophilainfection.- Type I interferons in immune defense against streptococci.- Activation of type I IFN signaling byStaphylococcus aureus.-Contribution of interferon signaling to host defense againstPseudomonas aeruginosa.-The detrimental role of type I interferon signaling during infection withSalmonellatyphimurium.- Yersiniaactivation of type I interferon.- Induction and Function of Type I IFNs During Chlamydial Infection.- Regulation of Host Response to Mycobacteria by Type I Interferons.