Basic and Clinical Neurocardiology

Hardcover | April 21, 2004

EditorJ. Andrew Armour, Jeffrey L. Ardell

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The progression of heart disease is associated with changes in the neurohumoral mechanisms that control cardiac function. The degree to which this neurohumoral remodeling occurs, even before overt signs of cardiac disease become manifest, is important for prognosis. To determine why somepatients experience sudden death while others sustain life in the presence of severely compromised cardiac function, the neuronal control of cardiac electrical and mechanical events must be considered. Starting at the level of individual neurons and building upwards, this book describes thesynergistic interactions that occur among intrathoracic and CNS feedback loops to permit precise control of regional cardiac behavior. On this basic science foundation, subsequent clinical chapters explore the remodeling that occurs in this system with aging, with the evolution of specific cardiacpathologies, and with the psychological concomitants of heart disease. Most importantly, these chapters provide unique insights into how specific therapies like beta-andrenergic receptor blockade not only affect cardiomyocytes directly but also mitigate the adverse neurohumoral changes thataccompany disease processes, such as heart failure and essential hypertension. The paradigm advanced in this volume is that heart disease is a multifaceted phenomenon involving the interplay of neurohumoral, cardiomyocyte and structural elements, each of which depends on the other. With ourcumulative understanding of these interdependent processes, new avenues for time-appropriate, targeted methods of treating heart diseases can be developed.

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The progression of heart disease is associated with changes in the neurohumoral mechanisms that control cardiac function. The degree to which this neurohumoral remodeling occurs, even before overt signs of cardiac disease become manifest, is important for prognosis. To determine why somepatients experience sudden death while others s...

J. Andrew Armour is an Associate Professor of Pharmacology at the University of Montreal Faculty of Medicine. Jeffrey L. Ardell is a Professor of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University.

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Format:HardcoverDimensions:480 pages, 6.42 × 9.41 × 1.61 inPublished:April 21, 2004Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195141296

ISBN - 13:9780195141290

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Table of Contents

1. David J. Adams and Javier Cuevas: Electrophysiological Properties of Intrinsic Cardiac Neurons2. Magda Horackova: Colocalization of Multiple Neurochemicals in Mammalian Intrathoracic Neurons3. J.A. Armour and G.C. Kember: Cardiac Sensory Neurons4. Jeffrey L. Ardell: Intrathoracic Neuronal Regulation of Cardiac Function5. Robert D. Foreman, Mike JL DeJongste, and Bengt Linderoth: Integrative Control of Cardiac Function by Cervical and Thoracic Spinal Neurons6. Michael C. Andresen, Diana L. Kunze, and David Mendelowitz: Central Nervous System Regulation of the Heart7. David F. Cechetto: Forebrain Control of Healthy and Diseased Hearts8. Phyllis M. Gootman: Ontogeny of the Cardiac Nervous System9. James G. Dobson, Jr. and R.A. Fenton: Aging and Neural Responses in the Heart10. Christer Sylven: The Genesis of Pain during Myocardial Ischemia and Infarction11. Rene Cardinal and Pierre L. Page: Neuronal Modulation of Atrial and Ventricular Electrical Properties12. Louis J. Dell'Italia and Jeffrey L. Ardell: Sympathetic Nervous System in the Evolution of Heart Failure13. J. Michael Wyss, Scott H. Carlson, and Suzanne Oparil: The Pathogenesis of Hypertension14. Christine Gagnon, Srikanth Ramachandruni, Edith E. Bragdon, and David S. Sheps: Psychological Aspects of Heart Disease15. Jeffrey L. Ardell, Louis J. Dell'Italia and J. Andrew Armour: Remodeling of the Cardiac Neuronal Hierarchy in Heart Disease