Basic aspects of Catechol-O-methyltransferase and the clinical applications of its inhibitors

Hardcover | December 2, 2010

byErkki NissinenEditorErkki Nissinen

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Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use. Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors Preclinical models in COMT inhibitor devlopment Transgenic COMT mice latest information summarized Chemistry of COMT inhibitors and their design with molecular modelling COMT gene and its regulation and relation to dopamine related diseases Role of cofactor SAM regulation in relation to homocysteine Nonclinical and clinical safety of COMT inhibitors summarized Future prospects of COMT inhibitors in Parkinson's disease

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Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future ...

Format:HardcoverDimensions:336 pages, 9 × 6 × 0.98 inPublished:December 2, 2010Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123813263

ISBN - 13:9780123813268

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Table of Contents

  1. Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson's disease with dual enzyme inhibition
  2. Erkki Nissinen

  3. The catechol-O-methyltransferase gene, its regulation and polymorphisms
  4. Elizabeth M. Tunbridge

  5. Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture?
  6. Timo T. Myöhänen & Pekka T. Männistö

  7. Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms
  8. Thomas Müller

  9. Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors
  10. Erkki Nissinen and Pekka T. Männistö

  11. The Chemistry of Catechol-O-methyltransferase Inhibitors
  12. David A. Learmonth, László E. Kiss and Patrício Soares-da-Silva

  13. Toxicology and safety of COMT inhibitors
  14. Kristiina Haasio

  15. Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment
  16. Concepció Marin, J.A. Obeso

  17. Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson's disease
  18. Seppo Kaakkola

  19. Catechol-O-methyltransferase and pain

Oleg Kambur & Pekka T. Männistö